Male-driven evolution of DNA sequences

Nature
L C ShimminW H Li

Abstract

It is commonly believed that the mutation rate is much higher in the human male germ line than in the female germ line because the number of germ-cell divisions per generation is much larger in males than in females. But direct estimation of mutation rates is difficult, relying mainly on sex-linked genetic diseases, so the ratio (alpha m) of male to female mutation rates is not clear. It has been noted that if alpha m is very large, then the rate of synonymous substitution in X-linked genes should be only 2/3 of that in autosomal genes, and comparison of human and rodent genes supported this prediction. As the number of X-linked genes used in the study was small and the X-linked and autosomal sequences were non-homologous, and given that the synonymous rate varies among genes, we sequenced the last intron (approximately 1 kb) of the Y-linked and X-linked zinc-finger-protein genes (ZFY and ZFX) in humans, orang-utans, baboons and squirrel monkeys. The ratio Y/X of the substitution rate in the Y-linked intron to that in the X-linked intron is approximately 2.3, which is close to that estimated from synonymous rates in the ZFY and ZFX genes and implies alpha m approximately 6. This estimate of alpha m supports the view that the ev...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Apr 1, 1991·Journal of Molecular Evolution·J Lanfear, P W Holland
Jan 1, 1987·Cold Spring Harbor Symposia on Quantitative Biology·T MiyataT Yasunaga
Feb 1, 1986·Analytical Biochemistry·M Hattori, Y Sakaki
Aug 13, 1955·Lancet·L S PENROSE

❮ Previous
Next ❯

Citations

Jan 1, 1997·American Journal of Physical Anthropology·N O BianchiS D Pena
Nov 20, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M D Purugganan
Dec 1, 1994·Journal of Molecular Evolution·L C ShimminW H Li
Dec 1, 1996·Journal of Molecular Evolution·L BromhamP H Harvey
Jan 1, 1997·Journal of Molecular Evolution·S Easteal, G Herbert
Jul 12, 2005·Journal of Molecular Evolution·Sara A Sandstedt, Priscilla K Tucker
Sep 7, 2006·Journal of Molecular Evolution·M Paula Goetting-Minesky, Kateryna D Makova
Feb 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A I AgulnikV V Solovyev
Mar 4, 2006·International Journal of Legal Medicine·Devinder Singh NegiJavaregowda Nagaraju
Nov 16, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Darren K Griffin
Nov 24, 1998·Trends in Genetics : TIG·L D Hurst, H Ellegren
Nov 8, 2003·Gene·Dmitry A Filatov, Dave T Gerrard
Nov 16, 2002·Current Opinion in Genetics & Development·Wen Hsiung LiKateryna Makova
Jun 12, 2002·Biological Reviews of the Cambridge Philosophical Society·T Pizzari, T R Birkhead
Nov 5, 1997·Nature Genetics·H Ellegren, A K Fridolfsson
Oct 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·C Tsantes, M E Steiper
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·J W Foster, J A Graves
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·R SalmelinH Freund
Feb 6, 2013·International Journal of Epidemiology·Abraham Aviv, Ezra Susser
Apr 11, 2008·Molecular Biology and Evolution·Shigeki NakagomeRyuichi Masuda
Apr 25, 2002·Nucleic Acids Research·Jesper BrohedeHans Ellegren
Oct 19, 2001·Molecular Biology and Evolution·H MontellH Ellegren
Feb 28, 2002·Molecular Biology and Evolution·Lindell Bromham
May 29, 2002·Molecular Biology and Evolution·Dmitry A Filatov, Deborah Charlesworth
May 29, 2002·Molecular Biology and Evolution·Carrie-Ann Whittle, Mark O Johnston
Aug 30, 2002·Molecular Biology and Evolution·Gerald J WyckoffChung-I Wu
Mar 28, 2009·Biology Letters·Navin ElangoSoojin V Yi
Dec 1, 2006·Proceedings. Biological Sciences·Hans Ellegren
Aug 3, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lindell Bromham
Apr 3, 2004·Genome Research·Kateryna D MakovaFrancesca Chiaromonte
Jul 20, 2007·Journal of Virology·Aris KatzourakisMichael Tristem
Nov 10, 2013·Molecular Biology and Evolution·Gregg W C Thomas, Matthew W Hahn
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Carrie-Ann Whittle, Mark O Johnston
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·B H ChangW H Li

❮ Previous
Next ❯

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