Male effect pheromone tickles the gonadotrophin-releasing hormone pulse generator

Journal of Neuroendocrinology
Hiroaki OkamuraYuji Mori

Abstract

In sheep and goats, the primer pheromone produced by the male induces out-of-seasonal ovulation in anoestrous females, the so-called 'male effect.' Because the initial endocrine event following reception of the pheromone is the stimulation of pulsatile luteinising hormone (LH) secretion, the central target of the pheromone is considered to be the putative gonadotrophin-releasing hormone (GnRH) pulse generator. Using electrophysiological techniques to record multiple-unit activity (MUA) in close proximity to kisspeptin neurones in the arcuate nucleus (ARC) of Shiba goats, we found that bursts (volleys) of MUA occur at regular intervals, and repetitive bursts are invariably associated with discrete pulses of LH, suggesting that the ARC kisspeptin neurones may be the intrinsic source of the GnRH pulse generator. A brief exposure of female goats to the pheromone immediately elicited an instantaneous rise in MUA, which is followed by an MUA volley and an accompanying LH pulse, indicating that the pheromone signal is transmitted to a subset of the ARC kisspeptin neurones to activate them. Because it has been suggested that the neurokinin B and dynorphin coexpressed in those neurones play critical roles in generating rhythmic bursts, ...Continue Reading

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Citations

Apr 27, 2012·Domestic Animal Endocrinology·P A R Hawken, G B Martin
Aug 31, 2010·Brain Research·Naomi E RancePenny A Dacks
May 7, 2013·General and Comparative Endocrinology·Yu-Wen Chung-DavidsonWeiming Li
Apr 3, 2013·Hormones and Behavior·Aras Petrulis
Mar 26, 2013·General and Comparative Endocrinology·Mélanie JouhanneauMatthieu Keller
Dec 16, 2011·Physiology·Karen P Maruska, Russell D Fernald
Nov 2, 2019·BMC Genomics·Paul CannPatricia Nagnan-Le Meillour

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