Male Ejaculatory Endophenotypes: Revealing Internal Inconsistencies of the Concept in Heterosexual Copulating Rats

Frontiers in Behavioral Neuroscience
Itztli Trejo-SánchezGabriel Gutiérrez-Ospina

Abstract

Distinct manifestations of sexual behavior are conceived as separate phenotypes. Each sexual phenotype is assumed to be associated with a characteristic brain. These notions have justified the phenotyping of heterosexual copulator males based upon their ejaculation's latencies (EL) or frequencies (i.e., cumulative ejaculation number; EN). For instance, men and male rats showing premature, normal or retarded ejaculation are assumed to be distinctive endophenotypes. This concept, nonetheless, contradicts past and recent evidence that supports that sexual behavior is highly variable within each sex, and that the brain sexual functional morphology represents an intricate sexual phenotypic mosaic. Hence, for ejaculatory male endophenotypes to be considered as a valid biological concept, it must show internal consistency at various levels of organization (including genetic architectures), after being challenged by intrinsic and/or extrinsic factors. We then judged the internal consistency of the presumed ejaculatory endophenotypes by assessing whether copulatory behavior and the expression of copulation relevant genes and brain limbic structures are specific to each of the presumed EL- or EN-ejaculatory endophenotypes. To do this, co...Continue Reading

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Citations

Dec 18, 2020·Frontiers in Behavioral Neuroscience·Vic Shao-Chih Chiang, Jin Ho Park

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Methods Mentioned

BETA
Polymerase Chain Reaction
electrophoresing
PCRs
PCA

Software Mentioned

Norm Finder
R Core Team
Graph Pad Prism
Probe Finder

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