Male-female differences in quality of life and coping style in patients with Marfan syndrome and hereditary thoracic aortic diseases.

Journal of Genetic Counseling
Carlijn G E ThijssenRoland R L van Kimmenade

Abstract

Hereditary thoracic aortic diseases (HTAD) such as Marfan syndrome (MFS) affect multiple organ systems and provide a risk of acute aortic dissection, which causes lifelong uncertainties. Although health-related quality of life (HRQOL) was found to be reduced in HTAD patients, no studies have evaluated male-female-specific aspects of HRQOL and coping in this population. This study aims to evaluate HRQOL in HTAD patients compared to the general population; assess male-female differences in HRQOL and factors associated with HRQOL; evaluate coping styles in male and female HTAD patients and identify factors associated with acceptance. All consecutive adult patients who visited the specialized HTAD outpatient clinic between 2013 and 2018 were asked to complete three HRQOL questionnaires: the Short Form 36 (SF-36), the Hospital Anxiety and Depression Scale (HADS), and the Nijmegen Clinical Screening Instrument (NCSI). In total, 142 patients were included (mean age 42.1 years, 65 females, 123 MFS). Compared to the general population, HTAD patients scored significantly lower on multiple SF-36 sub-domains (males: General Health 54.5 ± 18.8 vs. 71.6 ± 20.6, p < .001; Vitality 58.3 ± 20.4 vs. 71.9 ± 18.3, p < .001; females: Physical Funct...Continue Reading

References

Apr 13, 1972·The New England Journal of Medicine·J L MurdochV A McKusick
Aug 1, 1993·Journal of Personality and Social Psychology·C S CarverK C Clark
Jun 4, 1998·Journal of Medical Genetics·A Van Tongerloo, A De Paepe
Oct 31, 2001·Clinical Genetics·K F PetersB B Biesecker
Feb 8, 2002·Journal of Psychosomatic Research·Ingvar BjellandDag Neckelmann
Nov 27, 2002·European Archives of Psychiatry and Clinical Neuroscience·J AngstUNKNOWN Depression Research in European Society Study
Sep 26, 2006·The Annals of Thoracic Surgery·Gonzalo AlbornozJohn A Elefteriades
Jun 23, 2009·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jeannette Bernadette PetersJan H Vercoulen
Dec 25, 2009·Circulation. Cardiovascular Quality and Outcomes·Colleen M NorrisUNKNOWN APPROACH Investigators
Jul 2, 2010·Journal of Medical Genetics·Bart L LoeysAnne M De Paepe
Jul 9, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Svend Rand-HendriksenArnstein Finset
Oct 11, 2012·PloS One·Dounya SchoormansAeilko H Zwinderman
Dec 24, 2013·Respiratory Medicine·Jeannette B PetersJan H Vercoulen
Dec 8, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Petra OpićElisabeth M W J Utens
Jun 25, 2015·Heart, Lung & Circulation·Emily ConnorsIlona Juraskova
Jan 9, 2016·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Beata Jankowska-PolańskaDonald E Morisky
Aug 1, 2013·Aorta : Official Journal of the Aortic Institute at Yale-New Haven Hospital·Christian Olsson, Anders Franco-Cereceda
Jun 3, 2016·Health and Quality of Life Outcomes·Ju Ryoung MoonDuk-Kyung Kim
Jun 10, 2017·Journal of the American College of Cardiology·Judith Z GoldfingerUNKNOWN GenTAC Registry Consortium
Oct 3, 2018·The Journal of Pediatrics·Jill C HandisidesUNKNOWN Pediatric Heart Network Investigators

❮ Previous
Next ❯

Methods Mentioned

BETA
dissections
dissection

Software Mentioned

SPSS Statistics
SPSS

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.