Male Fertility Preservation

Current Urology Reports
J Abram McBride, Larry I Lipshultz

Abstract

With improvements in cancer treatment outcomes and an increase in cancer survivorship, understanding the importance of fertility preservation options prior to undergoing cancer treatment is essential. Therefore, we review herein the effect of cancer and its treatment on male fertility, the rationale for sperm cryopreservation, options for sperm retrieval, ART outcomes, and experimental options. Recent data update fertility outcomes with newer cancer therapies and provide longitudinal insight into survivor paternity with and without fertility preservation. Likewise, updated ART outcomes and future preservation options are discussed. The effect of cancer and its treatment on spermatogenesis is well established. Sperm cryopreservation is the best pre-treatment insurance for the opportunity of future fertility. Post-therapy patients may also achieve fertility restoration with ART, using cryopreserved or freshly obtained sperm. Meanwhile, utilization of cryopreserved testicular stem cells for future transfer or for in vitro maturation represents exciting alternatives on the horizon.

References

Jan 1, 1989·The Journal of Endocrinology·S M ShaletG Read
Mar 1, 1987·The Journal of Urology·P R CarrollR S Chaganti
Mar 1, 1985·International Journal of Radiation Oncology, Biology, Physics·B A FraassE Glatstein
Oct 15, 1983·British Medical Journal·J WaxmanT A Lister
Apr 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P M PetersenN E Skakkebaek
Mar 1, 1994·Annals of Hematology·C BokemeyerH Poliwoda
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·S Howell, S Shalet
Jul 13, 1999·Medical and Pediatric Oncology·C Sklar
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M N DamaniV Masters
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leslie R SchoverSima Jeha
Sep 25, 2002·International Journal of Andrology·S J Howell, S M Shalet
Nov 15, 2002·Acta Dermato-venereologica·Isabel LongoNatividad Longo
Oct 11, 2005·Fertility and Sterility·Joseph FeldschuhAllen Levine
Jan 10, 2006·Journal of Andrology·Moshe WaldCraig S Niederberger
Jan 21, 2006·The Journal of Sexual Medicine·Ahmed I El-SakkaKhalid A Tayeb
May 3, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephanie J LeeUNKNOWN American Society of Clinical Oncology
Oct 13, 2006·BJU International·Christopher R GirasoleSam S Chang
Mar 1, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Eric HuygheLionel Rostaing
Dec 14, 2007·Andrologia·A Jung, H-C Schuppe
Nov 28, 2008·Urology·Edmund S Sabanegh, Ahmed M Ragheb
Dec 19, 2008·The Journal of Urology·Daniel H WilliamsLarry I Lipshultz
Jan 31, 2009·International Journal of Andrology·O StåhlA Giwercman
Feb 25, 2009·Archives of Internal Medicine·Thomas J WalshPaul J Turek
Dec 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel M GreenLeslie L Robison

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Citations

Apr 14, 2019·International Journal of Molecular Sciences·Cristina Perez-PatiñoInmaculada Parrilla
Feb 11, 2020·Seminars in Reproductive Medicine·Anne E Martini, Joseph O Doyle
Jun 2, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Martin SalzmannJessica C Hassel

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