Male gonadal function after chemotherapy for solid tumors in childhood

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
F AubierJ Lemerle

Abstract

The testicular function of 30 adolescent or adult males having undergone polychemotherapy in childhood was assessed by means of a spermogram or testicular biopsy. At the time of examination, the patients were pubertal and had completed chemotherapy between 1 and 20 years previously (mean, 9 years). All patients who were prepubertal or intrapubertal at the time of treatment achieved normal puberty with normal growth. Twenty patients presented with azoospermia and/or severe disturbances in the germinal line on biopsy. This series confirms the toxicity of alkylating agents, in particular that of the mechlorethamine, vincristine, procarbazine, and prednisone combination (MOPP) and that of cyclophosphamide (CPM). However, dactinomycin, vinblastine, and vincristine did not appear to have a toxic effect on spermatogenesis. The prepubertal state did not protect the gonads of 19 patients who were prepubertal at diagnosis: 12 are now sterile as a result of the treatment. An increase in basal follicle-stimulating hormone (FSH) levels gives a good indication of testicular damage, although normal levels do not rule out the possibility of azoospermia.

Citations

Feb 15, 1991·Hospital Practice·A T Meadows
Jun 1, 1995·Medical and Pediatric Oncology·C MustielesR Barrio
Jul 6, 2000·Medical and Pediatric Oncology·T RelanderM Willén
Jun 30, 2004·Leukemia & Lymphoma·Lorna Zadravec ZaletelBerta Jereb
Apr 24, 2008·Acta Paediatrica·P M LähteenmäkiJ Toppari
Apr 15, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Kirsi JahnukainenJan-Bernd Stukenborg
Feb 13, 2017·The Journal of Urology·Emilie K JohnsonTeresa K Woodruff
Feb 19, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Hannah L NewtonAdam W Glaser
Apr 26, 2000·Pediatric Hematology and Oncology·M W Ben ArushA Kuten
May 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J H DalleC Patte
Feb 4, 2005·Human Reproduction·G BahadurD J Ralph
Sep 25, 2004·Pediatric Blood & Cancer·Wendy L HobbieAnna T Meadows
Sep 26, 2006·Human Reproduction·Loredana GandiniAndrea Lenzi
Nov 26, 2010·Expert Review of Hematology·Houchingue Eghbali, Aline Papaxanthos-Roche
Jun 1, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa B KenneyLillian Meacham
Oct 6, 2012·The Journal of Clinical Endocrinology and Metabolism·Kirsi Jahnukainen, Jan-Bernd Stukenborg
Jan 18, 2018·Arthritis & Rheumatology·Claire T DeakinUNKNOWN Juvenile Dermatomyositis Research Group
Dec 19, 2019·Journal of Clinical Medicine·Ylenia DucaAldo E Calogero
Sep 1, 1992·Archives of Disease in Childhood·C R Pinkerton
Feb 1, 1991·Cancer·J ZuazuA Flores
Dec 1, 1992·The Journal of Urology·E Shapiro, D Strother
Nov 22, 2001·Journal of Endocrinological Investigation·F B Diamond, B B Bercu
Jan 1, 1996·Medical and Pediatric Oncology·S KlieschE Nieschlag
Dec 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel M GreenLeslie L Robison
Mar 16, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wayland HsiaoPeter N Schlegel
Sep 1, 2010·Radiology and Oncology·Lorna Zadravec ZaletelBerta Jereb
Mar 30, 2010·International Journal of Andrology·P RomeriusA Giwercman
Sep 1, 1990·Acta Psychiatrica Scandinavica·P RopponenM A Siimes
Apr 11, 2001·Pediatric Hematology and Oncology·M P NahumM Weyl Ben Arush
May 1, 1995·Pediatric Hematology and Oncology·M A SiimesI Sipilä
Feb 1, 1992·Acta Psychiatrica Scandinavica·P RopponenV Aalberg
Sep 20, 2017·Journal of Clinical Medicine·Hamoun RozatiChanna N Jayasena
May 23, 1998·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·R B Mosher, B J McCarthy
Jan 16, 1999·Pediatric Clinics of North America·M Grossi
Aug 21, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardSeyed Abdulmajid Ayatollahi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
G P CanellosB A Peterson
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
S VivianiG Bonadonna
© 2022 Meta ULC. All rights reserved