Male Infertility and Sperm DNA Fragmentation

Open Access Macedonian Journal of Medical Sciences
Afrim ZeqirajAgim Shabani

Abstract

One of the main factors affecting male infertility is DNA fragmentation in sperm. Male infertility is a heterogeneous group of disorders, known causes account for only 30-50%, and unknown cause (idiopathic) constitute the rest. Infertility involves nearly 15% of couples in the reproductive age, and only the male problem involves about 40% of the problems. We have studied our DNA damage to sperm cells of a group of infertile males (113 patients) with abnormal sperm parameters (oligoasthenospermia and oligospermia) and a group of male patients (80 patients) with normal semen parameters (normospermia) to document whether the Sperm Chromatin Dispersion (SCD) analysis could increase the information obtained from the sperm routine analysis to explain the causes of infertility. A group of 193 patients were analysed, 113 patients in the working group and 80 patients in the control group were screened. The ejaculate samples were taken by the patient to whom the reason for the analysis was explained. All patients were from the Republic of Kosovo. Samples are collected from 2014/2018. Sperm Chromatin Dispersion (SCD) analyses in the ejaculate were analysed by the Biolab Zafi laboratory in Peja. Clinical data were compared between the two ...Continue Reading

Citations

Jul 9, 2020·Frontiers in Veterinary Science·Arumugam KumaresanJane M Morrell
Dec 10, 2020·The Journal of Clinical Endocrinology and Metabolism·Aditi SharmaChanna N Jayasena
Nov 4, 2020·Reproductive Sciences·Zahra BashiriMorteza Koruji

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