PMID: 11897917Mar 19, 2002Paper

Male infertility: tales of progress and frustration

Human Fertility : Journal of the British Fertility Society
W Chris L Ford

Abstract

This article describes andrology research, inspired by Professor Michael Hull, to develop sperm function tests and to understand the basic causes of male infertility. No generally acceptable sperm function test has yet been devised. Computer-assisted semen analysis (CASA) proved of limited value in predicting the outcome of in vitro fertilization (IVF) although it was more useful in donor insemination. High intracellular Ca2+ activity, [Ca2+]i, is involved in decreasing motility in cryopreserved sperm. Capacitative calcium entry after depletion of intracellular stores may generate the sustained increase in [Ca2+]i that initiates the acrosome reaction. Our data support the presence of Ca2+ stores as thapsigargin increased [Ca2+]i in sperm in Ca2+ -free medium. Recent observations indicate that cAMP enhances capacitative calcium entry, acting upstream of emptying of the store. Excess reactive oxygen species (ROS) is an important cause of sperm pathology but at low concentrations ROS regulate capacitation. Our evidence shows that ROS are produced by leucocytes present in sperm suspensions. We have been unable to demonstrate that human sperm produce ROS. The relationship between ROS production and lipid peroxidation indicates that ...Continue Reading

References

Jun 30, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R Jones, T Mann
Jun 5, 1978·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R JonesR J Sherins
Nov 14, 1992·Lancet·S K RosevearM G Hull
Sep 1, 1992·Fertility and Sterility·D Y Liu, H W Baker
Mar 1, 1992·Journal of Reproduction and Fertility·E KessopoulouI D Cooke
Jan 1, 1991·Annals of the New York Academy of Sciences·C GagnonN Kovalski
Mar 1, 1991·Biology of Reproduction·I BizeC Sharpe
Apr 1, 1990·Fertility and Sterility·J M YovichJ L Yovich
Sep 1, 1990·Journal of Reproduction and Fertility·J M ReesM G Hull
Dec 14, 1985·British Medical Journal·M G HullK M Desai
Aug 31, 1973·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R Jones, T Mann
Jun 1, 1995·Fertility and Sterility·H Wolff
Jan 1, 1997·Archives of Biochemistry and Biophysics·S I Liochev, I Fridovich
Jul 23, 1998·Biology of Reproduction·P E Visconti, G S Kopf
Aug 6, 1998·Baillière's Clinical Obstetrics and Gynaecology·P L Matson
Aug 12, 1999·International Journal of Andrology·K WhittingtonW C Ford
May 20, 2000·Annals of the New York Academy of Sciences·B C Tarlatzis, H Bili
Mar 3, 2001·Molecular Human Reproduction·S C Richer, W C Ford
Mar 10, 2001·Paediatric and Perinatal Epidemiology·J GoldingUNKNOWN ALSPAC Study Team
Jun 22, 2001·Lancet·W C Ford
Mar 19, 2002·Human Fertility : Journal of the British Fertility Society·Cathryn M A Glazener, W Chris L Ford

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.