Male microchimerism and survival among women

International Journal of Epidemiology
Mads Kamper-JørgensenAnne Tjønneland

Abstract

During pregnancy, woman and fetus exchange small quantities of cells, and their persistence at later times is termed microchimerism. Microchimerism is known to substantially impact on women's later health. This study examined the survival of women according to male microchimerism status. Male microchimerism presence, measured as Y chromosome in peripheral blood samples, was determined in 272 women from the large Danish Diet, Cancer and Health cohort when aged 50-64 years during 1993-97. Women were followed up for cause-specific death in national Danish registers until the end of 2009. Survival was analysed using Cox regression. A total of 190 women (70%) were male microchimerism positive. During follow-up 21 women died, of whom 11 (52%) were male microchimerism positive at enrolment and 10 were negative. Of the 21 deaths, 13 (62%) were due to cancer and 5 (24%) were due to cardiovascular disease. Male microchimerism presence was associated with a reduced hazard ratio of all-cause mortality of 0.42 (95% CI 0.17-1.03). The hazard ratio of death from cancer and cardiovascular disease was 0.24 (95% CI 0.08-0.79) and 1.66 (95% CI 0.18-15.48), respectively, among male microchimerism positive compared with negative women. Although the...Continue Reading

References

Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D W BianchiM A DeMaria
Mar 15, 1997·BMJ : British Medical Journal·T WestergaardM Melbye
May 8, 1998·Obstetrics and Gynecology·W HolzgreveS Hahn
Nov 24, 2001·BMJ : British Medical Journal·H U IrgensR T Lie
Jul 18, 2006·Journal of Neuroimmunology·Cristen J WillerUNKNOWN Canadian Collaborative Study on Genetic Susceptibility to Multiple Sclerosis
Sep 12, 2007·Vox Sanguinis·G H UtterM P Busch
Oct 3, 2007·Cancer Research·Vijayakrishna K Gadi, J Lee Nelson
Nov 15, 2007·American Journal of Epidemiology·Emily Grundy, Øystein Kravdal
May 30, 2008·Experimental Hematology·Gary L GilmoreJohn Lister
Jan 5, 2011·Cancer Research·Lisa R KallenbachDiana W Bianchi
Aug 4, 2011·Scandinavian Journal of Public Health·Karin Helweg-Larsen
Aug 4, 2011·Scandinavian Journal of Public Health·Marianne Lundkjær Gjerstorff
Nov 16, 2011·Circulation Research·Rina J KaraHina W Chaudhry
Mar 9, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mads Kamper-JørgensenVijayakrishna K Gadi
Mar 31, 2012·Age and Ageing·Leon A SimonsJohn McCallum
Oct 17, 2012·European Journal of Epidemiology·Signe Benzon LarsenAnja Olsen
Nov 7, 2012·Chimerism·Mads Kamper-Jørgensen

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Citations

Mar 4, 2014·International Journal of Epidemiology·Caroline L Relton
Sep 23, 2014·Cellular & Molecular Immunology·Hilary S GammillJ Lee Nelson
Jun 25, 2015·International Journal of Cancer. Journal International Du Cancer·Valentina CirelloLaura Fugazzola
Aug 2, 2015·Neuroscience·J A DiPietro, K M Voegtline
Jan 28, 2017·Nature Neuroscience·Cindy K Barha, Liisa A M Galea
Aug 14, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·R ShreeH S Gammill
Feb 15, 2019·Reproductive Biology and Endocrinology : RB&E·Muzaffer A BhatDebabrata Ghosh
Jun 27, 2018·Clinical Chemistry·Diana W Bianchi
Oct 24, 2020·Obstetric Medicine·Heidi Es FjeldstadAnne Cathrine Staff
Nov 14, 2020·American Journal of Epidemiology·Sara HallumMads Kamper-Jørgensen

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