Male offspring of both diabetic parents have higher insulin resistance and serum leptin levels compared to those with one diabetic parent

Hormones : International Journal of Endocrinology and Metabolism
Adeela ShahidMuhammad Arslan

Abstract

We studied the influence of positive family history (FH) of type 2 diabetes mellitus (T2DM) in male offspring using multiple metabolic and endocrine parameters in order to assess whether one or more of these parameters can be used as indicators for T2DM development later in life. Fifty male subjects with one diabetic parent (ODP) and thirty with both diabetic parents (BDP) were compared with fifty, age-matched, offspring of non-diabetic parents (NDP). Body weight, height, BMI and blood pressure were determined in all subjects. Fasting blood samples were analyzed for glucose, HbA1-c, insulin, C-peptide, leptin and lipid profile. A 2h oral glucose tolerance test (2h-OGTT) was also carried out. Insulin resistance (IR) was assessed by HOMA-IR index. Mean serum levels of glucose (fasting and following 2h-OGTT), C-peptide and leptin in male offspring of diabetic parents were higher than in male offspring of NDP. Mean fasting serum insulin and triglycerides were higher in boys of BDP compared to those of ODP and NDP. HOMA-IR was markedly high in ODP and BDP groups when compared with the NDP group. No stastically significant difference was observed in the HbA1-c values between any of the groups studied. These results indicate that T2DM...Continue Reading

Citations

Dec 8, 2015·Annales d'endocrinologie·Qasim M JanjuaMuhammad Arslan
Dec 1, 2012·Atherosclerosis·Marcieli da Luz GiroldoDalton Bertolim Précoma
Aug 17, 2010·Diabetes Technology & Therapeutics·Edavan P PraveenAriachery C Ammini
Sep 2, 2018·Hormones : International Journal of Endocrinology and Metabolism·Uzma ZafarKhalid P Lone
Sep 7, 2021·Frontiers in Cell and Developmental Biology·Hamed JanbazacyabarSaskia Braber

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