Male prairie voles display cardiovascular dipping associated with an ultradian activity cycle

Physiology & Behavior
Robert Lewis, J Thomas Curtis

Abstract

Mammals typically display alternating active and resting phases and, in most species, these rhythms follow a circadian pattern. The active and resting phases often are accompanied by corresponding physiological changes. In humans, blood pressure decreases during the resting phase of the activity cycle, and the magnitude of that "nocturnal dipping" has been used to stratify patients according to the risk for cardiovascular disease. However, in contrast to most mammals, prairie voles (Microtus ochrogaster) have periods of activity and rest that follow an ultradian rhythm with period lengths significantly <24h. While rhythmic changes in blood pressure across a circadian activity cycle have been well-documented, blood pressure patterns in species that display ultradian rhythms in activity are less well-studied. In the current study, we implanted pressure-sensitive radiotelemetry devices in male prairie voles and recorded activity, mean arterial pressure (MAP), and heart rate (HR) continuously for 3days. Visualization of the ultradian rhythms was enhanced using a 1h running average to filter the dataset. Positive correlations were found between activity and MAP and between activity and HR. During the inactive period of the ultradian...Continue Reading

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Citations

Mar 27, 2018·PloS One·J Thomas CurtisGerwald A Köhler
Apr 22, 2021·Journal of Biological Rhythms·Laura van Rosmalen, Roelof A Hut
Jun 26, 2021·Current Protocols·William M KenkelAnnaliese K Beery

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