Male reproductive and behavior toxicity in rats after subchronic exposure to organic extracts from Jialing River of Chongqing, China

Birth Defects Research. Part B, Developmental and Reproductive Toxicology
Zhihong CuiJia Cao

Abstract

More than 100 species of organic chemicals have been detected in Jialing River of Chongqing City. Most of them are endocrine-disrupting chemicals (EDCs), which can disrupt the functions of the reproductive and nervous systems. Organic extracts (OE) were obtained by solid extraction from the Jialing River, and administrated to rats by gavage every other day for 13 weeks at doses of 2, 12, and 72 L/kg bw/d. Sperm abnormity was analyzed by microscopy and flow cytometry. The Morris water maze task was employed to investigate the behaviors of space probing. Activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) content were measured to detect the peroxidation response in hippocampus and testis. Animals in the 72-L/kg group showed significant degeneration of germ cells in the seminiferous tubule. Sperm abnormality of the 72-L/kg group was significantly higher than that of the solvent control group. The testis oxidative stress in the 72-L/kg group was severer than that of the other groups. The hippocampus neuron cells in the 72-L/kg group showed cellular edema and remarkable cell enlargement. The hippocampus oxidative stress in the 72-L/kg group was severer and the Morris water maze perf...Continue Reading

References

May 1, 1984·Journal of Neuroscience Methods·R Morris
Oct 22, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T Tanaka
Mar 26, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Caroline M MarkeyCarlos Sonnenschein
Mar 16, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Jane S Fisher
Nov 8, 2005·Molecular and Cellular Endocrinology·R H Waring, R M Harris
Aug 15, 2006·Toxicology·Giuseppe LatiniClaudio De Felice
Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Apr 13, 2007·Hormones and Behavior·Luca CorrieriLeonida Fusani
Jun 24, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ismail Celik, Huseyin Suzek
Jun 6, 2009·Journal of Toxicology and Environmental Health. Part a·Zhihong CuiJia Cao
Jun 9, 2009·Endocrine Reviews·Evanthia Diamanti-KandarakisAndrea C Gore
Jun 18, 2009·Journal of Applied Toxicology : JAT·Yuanfeng LiNian Shi

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Citations

Apr 24, 2013·Environmental Science and Pollution Research International·Tilman FloehrHenner Hollert
Mar 25, 2011·Ecotoxicology·Dayong ZhaoXuxiang Zhang

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