Male sex and history of ischemic heart disease are major risk factors for anastomotic leakage after laparoscopic anterior resection in patients with rectal cancer

BMC Gastroenterology
Seiichi ShinjiHiroshi Yoshida

Abstract

Anastomotic leakage (AL) is the most serious and common complication of surgery for rectal cancer, and associated risk factors remain unknown despite developments in laparoscopic surgery. The present study aimed to determine risk factors for AL after laparoscopic anterior resection (AR) of rectal cancer. This retrospective cohort study extracted information from a prospective database of all consecutive colorectal resections that proceeded at Nippon Medical School Hospital between January 2011 and December 2015 (n = 865). We identified 154 patients with rectal cancer treated by elective laparoscopic AR with anastomosis using primary double-stapling. Clinical variables and comorbidity, habits, and surgery-related variables were assessed by univariate and multivariate analyses to determine preoperative risk factors for clinical AL. The overall rate of clinical AL was 11.7% (18 of 154 patients), and 5 (27.8%) of 18 patients required revised laparotomy. Data from males were analyzed because AL occurred only in males. Univariate analysis of male patients (n = 100) significantly associated preoperative creatinine values (p = 0.03) and a history of ischemic heart disease (IHD) (p = 0.012) with AL. The frequency of AL tended to increas...Continue Reading

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Citations

May 9, 2019·Gastroenterology Research and Practice·Ulysses RibeiroSilvio M Junqueira
Nov 30, 2019·International Journal of Clinical Oncology·Tunyaporn KamonvarapitakHiroshi Yoshida
Dec 23, 2019·Surgery Today·Mizunori YaegashiAkira Sasaki
Aug 31, 2020·The Journal of International Medical Research·Lei NiuXiaomu Zhao
Oct 31, 2020·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Alban Zarzavadjian Le BianDavid Fuks

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