Male-specific submaxillary gland protein, a lipocalin allergen of the golden hamster, differs from the lipocalin allergens of Siberian and Roborovski dwarf hamsters

International Archives of Allergy and Immunology
Christiane HilgerFrançois Hentges

Abstract

An increasing number of asthma cases upon exposure to hamsters and anaphylactic reactions following hamster bites are being reported, but the allergens responsible are still poorly characterized. In the Golden hamster, male-specific submaxillary gland protein (MSP), a lipocalin expressed in a sex- and tissue-specific manner in the submaxillary and lacrimal glands, is secreted in the saliva, tears and urine. The purpose of this study was to determine if MSP is an allergen, to identify IgE-reactive proteins of different hamster species and to analyse potential cross-reactivities. Fur extracts were prepared from four hamster species. Hamster-allergic patients were selected based on a history of positive IgE-test to hamster epithelium. The IgE-reactivity of patients' sera was investigated by means of immunoblot and ELISA. IgE-reactive proteins in fur extracts and the submaxillary gland were identified using anti-MSP antibodies, Edman sequencing or mass spectrometry. MSP was purified from Golden hamster and recombinant MSP was expressed in E. coli. Four patients had IgE-antibodies against 20.5-kDa and 24-kDa proteins of Golden hamster fur extract, which were identified as MSP. IgE-reactive MSP-like proteins were detected in European...Continue Reading

Citations

Jul 14, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Matteo MartiniChristiane Hilger
Oct 24, 2017·Veterinary Sciences·Eva Zahradnik, Monika Raulf
Aug 24, 2017·Current Allergy and Asthma Reports·Christiane HilgerAnnette Kuehn
Apr 3, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Kyra SwiontekChristiane Hilger
May 7, 2020·The World Allergy Organization Journal·Luis CaraballoAlexander Karaulov

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