Male urinary biomarkers of antimicrobial exposure and bi-directional associations with semen quality parameters

Reproductive Toxicology
Melissa M SmarrGermaine M Buck Louis

Abstract

Antimicrobials including parabens, triclosan, and triclocarban have endocrine disrupting properties. Among 501 male partners of couples planning to become pregnant, preconception urinary biomarkers of parabens, triclosan and triclocarban exposure were quantified in spot urine samples. Men also provided two fresh semen samples collected approximately one month to undergo 24-h semen quality analysis. Linear mixed-effects models, adjusted for creatinine, race, age and body mass index, were utilized to assess the relationship between log transformed chemical concentrations rescaled by their standard deviations and semen parameters. Methyl, ethyl and butyl parabens, were associated with diminished sperm count and several sperm motility parameters. Hydroxylated paraben metabolites and triclosan were significantly positively associated with select semen quality parameters. Overall, our findings suggest that specific urinary parabens found in consumer goods (methyl, ethyl and butyl parabens) may adversely impact sperm quality parameters among reproductive-age male partners of couples trying for pregnancy.

Citations

Jul 30, 2020·International Journal of Toxicology·Priya CherianBart Heldreth
Aug 1, 2020·International Journal of Environmental Health Research·Yaghoub HajizadehKarim Ebrahimpour
Aug 28, 2020·Toxics·Kajsa Ugelvig PetersenSandra Søgaard Tøttenborg
Jan 7, 2020·Journal of Applied Toxicology : JAT·Natalia MatwiejczukMałgorzata M Brzóska
Aug 20, 2019·Environmental Research·Feiby L NassanUNKNOWN EARTH Study Team
Jul 23, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Zvonimir PetricIrena Žuntar
Nov 23, 2020·Environmental Research·Karolina NowakWioletta Ratajczak-Wrona
Jun 19, 2021·Journal of the American Academy of Dermatology·Walter LiszewskiAndrew Scheman

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