Malformation of cortical development: which strategy is best?

Neuro-Chirurgie
Francine Chassoux

Abstract

Malformations of cortical development (MCD) correspond to a broad spectrum of cerebral lesions resulting from cortical development abnormalities during embryogenesis. They are frequently associated with drug-resistant epilepsy as well as more or less severe neurological and cognitive deficits. Diagnosis of MCD has greatly improved with the progress in contemporary imaging techniques, and patients with cryptogenic epilepsy are increasingly recognized as having MCD. Current classifications based on the combination of clinical, imaging, genetic and pathological data allow analysis of homogeneous patient series and optimal therapeutic strategies. Successful surgical treatment can be proposed to patients with focal lesions such as focal cortical dysplasia or tumors associated with cortical dysplasia (dysembryoplastic neuroepithelial tumors and gangliogliomas). Favorable outcome can also be obtained in some diffuse cases such as tuberous sclerosis, periventricular heterotopia and polymicrogyria. Invasive monitoring, especially stereoelectroencephalography (SEEG), has proved to be useful in determining the organization of the epileptogenic zone in each MCD type and planning cortical resections. Moreover, establishing correlations betw...Continue Reading

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Citations

Jun 12, 2014·Acta Neuropathologica·Imad M NajmGiorgio Lo Russo
Jun 1, 2013·La Presse médicale·Aurélie ChabrolBenoît Morel
Apr 18, 2008·Neuro-Chirurgie·I Jambaqué
Jun 11, 2009·Current Opinion in Oncology

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