Malformations of cortical development: New surgical advances

Revue neurologique
P BourdillonM Guénot

Abstract

Epilepsy related to malformations of cortical development is frequently drug resistant or requires heavy medication, therefore surgery is key in their management. The role of stereotactic surgery has recently changed the diagnosis and treatment of focal cortical dysplasias (FCD), hypothalamic hamartomas (HH) and periventricular nodular heterotopias (PNH). In HH, radiosurgery using Gammaknife® leads to 60 % of seizure control and is associated with excellent neuropsychological results without significant endocrine function impairment. The seizure control rate is even higher (more than 80 %) with monopolar multiple stereotactic thermocoagulations and Laser interstitial Thermal Therapy (LiTT). While the first technique is associated with a 2 % complications rate (but with excellent neuropsychological outcomes), the latest has up to 22 % side effects in some series. All three of these techniques have encouraging results, but controlled studies are still lacking to provide evidence-based new therapeutic algorithms. With regard to the PNH, surgical management has long been limited by the depth of the lesions and their close anatomical relations with the functional brain connectome. Stereotactic approaches required to perform a SEEG, ...Continue Reading

References

Oct 1, 1995·Brain : a Journal of Neurology·F DubeauF Andermann
Mar 1, 1994·Neurology·E AndermannN Lee
Jun 30, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jean RégisPatrick Chauvel
Jun 5, 2007·Seminars in Pediatric Neurology·Jean RégisPatrick Chauvel
Jun 5, 2007·Seminars in Pediatric Neurology·Jeffrey V Rosenfeld, Iman Feiz-Erfan
Apr 15, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·H DuffauE Mandonnet
Dec 9, 2010·Journal of Neurosurgery·Adib A AblaJohn F Kerrigan
Mar 5, 2011·Neurosurgical Focus·Jeffrey V Rosenfeld
May 24, 2011·World Neurosurgery·Hugues Duffau
Jun 4, 2013·Neurosurgical Focus·Sandeep MittalFrederick Andermann
Jun 4, 2013·Neurosurgical Focus·Sandeep MittalFrederick Andermann
Dec 18, 2013·Epilepsia·Angus A Wilfong, Daniel J Curry
Feb 13, 2014·Epilepsy Research·Yoshua EsquenaziNitin Tandon
Jun 28, 2014·Brain : a Journal of Neurology·Matthew C TateHugues Duffau
Nov 21, 2015·Journal of Neurosurgery·Shigeki KameyamaKohei Akazawa
Jan 7, 2016·Epilepsy Research·Hisaji ImamuraAkio Ikeda
Apr 10, 2016·Brain Topography·Mohammad-Reza Nazem-ZadehHamid Soltanian-Zadeh
Jul 28, 2016·Seizure : the Journal of the British Epilepsy Association·Stephen A ThompsonNitin Tandon
Sep 17, 2016·Neurosurgery·Ahmad AlhouraniR Mark Richardson
Jan 29, 2017·Neurology·Seok-Jun HongAndrea Bernasconi
Jun 8, 2017·Epilepsia·Frederic CastinettiJean Régis
Jun 18, 2017·Epilepsia·Maeike ZijlmansMichel Le Van Quyen
Jul 15, 2017·Epilepsy Research·Massimo CossuLaura Tassi
Dec 24, 2017·Neurophysiologie clinique = Clinical neurophysiology·Pierre BourdillonJean Isnard
Dec 27, 2017·Neurophysiologie clinique = Clinical neurophysiology·Jean IsnardPaul Sauleau
Feb 17, 2018·Journal of Neurosurgery. Pediatrics·Derek G SouthwellKurtis I Auguste

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Citations

Apr 23, 2020·Neurosurgical Review·Pierre BourdillonG Dorfmüller
Jul 22, 2020·World Neurosurgery·Claudia M Kuzan-FischerCaitlin E Hoffman
Apr 10, 2021·Expert Review of Neurotherapeutics·Renzo Guerrini, Carmen Barba
Jun 8, 2021·Neurología : publicación oficial de la Sociedad Española de Neurología·M Angulo-MaldonadoA Ulloa-Piza

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