Malian children with moderate acute malnutrition who are treated with lipid-based dietary supplements have greater weight gains and recovery rates than those treated with locally produced cereal-legume products: a community-based, cluster-randomized trial

The American Journal of Clinical Nutrition
Robert S Ackatia-ArmahKenneth H Brown

Abstract

Moderate acute malnutrition (MAM), defined as weight-for-length z score between -3 and -2 or midupper arm circumference between 11.5 and 12.5 cm, affects ∼33 million children aged <5 y worldwide. The objective was to compare the effects of 4 dietary supplements for the treatment of MAM. Twelve community health centers in rural Mali were randomly assigned to provide to 1264 MAM children aged 6-35 mo one of 4 dietary supplements containing ∼500 kcal/d for 12 wk: 1) ready-to-use, lipid-based supplementary food (RUSF); 2) special corn-soy blend (CSB++); 3) locally processed, fortified flour (Misola); or 4) locally milled flours plus oil, sugar, and micronutrient powder (LMF). In total, 1178 children (93.2%) completed the study. The adjusted mean (95% CI) change in weight (kg) from baseline was greater with RUSF than with the locally processed blends and was intermediate with CSB++ [1.16 (1.08, 1.24) for RUSF, 1.04 (0.96, 1.13) for CSB++, 0.91 (0.82, 0.99) for Misola, and 0.83 (0.74, 0.92) for LMF; P < 0.001]. For length change, RUSF and CSB++ differed significantly from LMF. Sustained recovery rates were higher with RUSF (73%) than with Misola (61%) and LMF (58%), P < 0.0001; CSB++ recovery rates (68%) did not differ from any of th...Continue Reading

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Citations

Jul 5, 2016·International Journal of Environmental Research and Public Health·Stefania MoramarcoErsilia Buonomo
Dec 23, 2017·Annual Review of Public Health·Colin W BinnsAndy H Lee
Nov 9, 2017·Nutrition Research Reviews·Veronika Scherbaum, M Leila Srour
Apr 28, 2018·Statistics in Medicine·Craig AndersonWilliam Checkley
Jan 8, 2016·The American Journal of Clinical Nutrition·Christian FabiansenSusan Shepherd
Oct 20, 2018·Journal of Food Science and Technology·Mary AdjepongJenifer I Fenton
Sep 19, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Imara GluningCharles Opondo

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