Malignancies and outcome in Takotsubo syndrome: a meta-analysis study on cancer and stress cardiomyopathy

Heart Failure Reviews
Natale Daniele BrunettiFrancesco Santoro

Abstract

Takotsubo syndrome (TTS) can be induced by a large variety of physical/emotional triggers; several cases, however, are related to either an overt or occult malignancy, as shown in retrospective studies and case reports. The aim of this study was therefore to evaluate the clinical outcome of patients with TTS and cancer in a meta-analysis study. In June 2018, a Pubmed systematic research was conducted for studies assessing outcome in patients with TTS and cancer. We assessed Mantel-Haenszel pooled estimates of risk ratios (RRs) and 95% confidence intervals (CIs) for adverse events at follow-up. After paper retrieval, four studies were included in the meta-analysis, with a total of 123,563 patients. The prevalence of current or previous malignancy among patients admitted with TTS was 6.7% (8258 patients). When compared to control patients, patients with cancer showed an increased risk of clinical events (RR 3.24, 95% CI 3.04-3.45, p < 0.01). The risk of in-hospital events was significantly higher in the cancer group (RR 2.08 95% CI, 1.50-2.87, p < 0.01) and was mainly due to higher need for respiratory support (RR 1.67, 95% CI, 1.58-1.77, p < 0.01). The risk of adverse events at follow-up was also higher in the cancer group (RR 3...Continue Reading

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Citations

Jul 18, 2019·Journal of the American Heart Association·Paolo Angelini, Carlo Uribe
Jul 28, 2019·QJM : Monthly Journal of the Association of Physicians·P TornvallH Pettersson
Jun 15, 2019·Heart Failure Reviews·Isabela Bispo Santos da Silva CostaLudhmila Abrahão Hajjar
Sep 19, 2020·Journal of Clinical Medicine·Charlotte DagrenatOlivier Morel
Jan 18, 2020·International Cancer Conference Journal·Toshihiko MatsumotoHirofumi Morishita
Oct 12, 2020·Current Cardiology Reports·Nicolas L PalaskasAnita Deswal
Aug 18, 2021·Scientific Reports·Francesco SantoroNatale Daniele Brunetti
Sep 28, 2021·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·María Eugenia García GuzzoSergio Adrián Terrasa
Dec 8, 2021·ESC Heart Failure·Kalliopi KeramidaGerasimos Filippatos

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