Malignancies in transplanted patients: Multidisciplinary evaluation and switch to mTOR inhibitors after kidney transplantation - experiences from a prospective, clinical, observational study

Acta Oncologica
Vivan C HellströmTomas Lorant

Abstract

Background Solid organ transplant recipients are at increased risk of developing malignancies. The objective of this prospective, observational, one-armed study was to study the feasibility to add a mammalian target of rapamycin (mTOR) inhibitor to the immunosuppressive regimen in transplanted patients with post-transplant malignancies. During the trial the need to improve identification of post-transplant malignancies and to reassure adequate oncological treatment of these patients became evident. Multidisciplinary team (MDT) evaluation of oncological and immunosuppressive treatments was implemented for all patients with malignancies after renal or combined renal and pancreas transplantation because of the trial. Material and methods At Uppsala University Hospital, Sweden, a MDT consisting of transplant surgeons, nephrologists, oncologists and dermatologists evaluated 120 renal or combined renal and pancreas-transplanted recipients diagnosed with malignancies from September 2006 to July 2012. To identify all malignancies, the population was linked to the Regional Tumor Registry (RTR). We recorded to which extent a switch to mTOR inhibitors was possible and how often the originally planned oncological managements were adjusted....Continue Reading

Associated Clinical Trials

Sep 16, 2014·Tomas Lorant

References

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Citations

Dec 7, 2019·Clinical Kidney Journal·Neus RocaGema Ariceta
Mar 29, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ben SprangersDaan Dierickx
Jul 9, 2021·Transplantation Reviews·Jacopo RomagnoliUNKNOWN Consensus Conference Expert Panel

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