PMID: 9166025Apr 1, 1997Paper

Malignancies in UK children with HIV infection acquired from mother to child transmission

Archives of Disease in Childhood
J A EvansA E Ades

Abstract

By April 1995, 302 cases of vertically acquired HIV infection had been reported through the British Paediatric Association Surveillance Unit. Over 50% of these children had developed an AIDS indicator disease, including nine malignancies (seven cases of non-Hodgkin's lymphoma (NHL) and two of Kaposi's sarcoma). There were two other malignancies that were not AIDS indicator diseases. In children less than 5 years of age the incidence of NHL was approximately 2500 times greater than expected in the UK child population. Three children presented with NHL as their AIDS indicator disease and four developed NHL at a median of 14 (range 10-19) months after the initial diagnosis of AIDS. Six of the seven children died at a median of 6.5 (range 2-14) months after the diagnosis of NHL. The seventh child responded to treatment and is alive nearly four years later. Histology was available in five cases, of which four were of B cell and one of T cell origin. Epstein-Barr virus was detected in all three patients with NHL where it was sought; all had B cell lymphomas. Although comparatively rare, malignancies occur in children infected with HIV and may be the presenting illness. Paediatricians now need to consider HIV infection as a predisposi...Continue Reading

References

Oct 1, 1992·Current Opinion in Oncology·R J Biggar, C S Rabkin
Oct 5, 1991·Lancet·S RoithmannJ M Andrieu
May 1, 1988·The Pediatric Infectious Disease Journal·J H KerseyA H Filipovich
Nov 18, 1995·Lancet·J C Noel
Aug 1, 1994·AIDS·B G HerndierM S McGrath
Jan 5, 1995·The New England Journal of Medicine·K L McClainS B Murphy
Jan 1, 1993·Medical and Pediatric Oncology·E G LyallN M Croft
May 15, 1993·BMJ : British Medical Journal·A E AdesC S Peckham
Nov 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C A StillerE M Eatock
May 1, 1996·Archives of Disease in Childhood·G A McCarthyD Gibb
Feb 1, 1996·Current Opinion in Pediatrics·B U Mueller, P A Pizzo

❮ Previous
Next ❯

Citations

Mar 21, 2009·Pediatric Radiology·Salomine TheronRobert Gie
Jun 20, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Alan Davidson, Marc Hendricks
Feb 19, 2002·Clinics in Dermatology·Christina StefanakiJohn D Stratigos
Dec 3, 1999·British Journal of Haematology·C R Pinkerton
May 17, 2000·AIDS Patient Care and STDs·B U Mueller
Mar 8, 2005·The Pediatric Infectious Disease Journal·Helen KestGeorge R Seage
Apr 1, 2008·Journal of Pediatric Hematology/oncology·Laura MartelliAndrea Ferrari
Sep 1, 2012·Journal of Pediatric Hematology/oncology·Cécile GodotMarie-Dominique Tabone
Feb 20, 2007·Pediatric Clinics of North America·Irena BukaAlvaro R Osornio Vargas
Dec 3, 2014·The Lancet Oncology·Daniela C Stefan
May 20, 2003·Revista do Hospital das Clínicas·Claudete Esteves KlumbRaquel Ciuvalschi Maia
Mar 4, 2000·Pediatric Clinics of North America·O R Abuzaitoun, I C Hanson
May 9, 2002·British Medical Bulletin·Stephen M Graham, Diana M Gibb
Jul 28, 2005·Pediatric Blood & Cancer·Alina FedorovaOlga Aleinikova
Dec 18, 2019·Cancer Metastasis Reviews·William KamiyangoNader Kim El-Mallawany
Feb 26, 2016·The Pediatric Infectious Disease Journal·Julia BohliusUNKNOWN for IeDEA-Southern Africa
Oct 8, 2016·Current Opinion in HIV and AIDS·Mary-Ann DaviesAnna Turkova
Nov 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D CaselliM Aricò
Dec 29, 2000·Annals of the New York Academy of Sciences·C E GonzalezI Magrath
Dec 5, 2020·International Journal of Environmental Research and Public Health·Ulla Arthur HvidtfeldtOle Raaschou-Nielsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

The Pediatric Infectious Disease Journal
Alejandro Alvaro-MecaSalvador Resino
Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology
Dattatray G SaplePrashant D Gote
© 2021 Meta ULC. All rights reserved