The eyelid can be the site of various malignant tumors, including epithelial, mesenchymal, lymphoproliferative, and endocrine neoplasms, all of which can present in unusual ways or mimic benign processes, often requiring biopsy for a definitive diagnosis. This review article presents a broad overview of some of the malignancies that have been reported to occur in eyelids, addressing clinical presentation and natural history, histologic and immunostaining characteristics, and genetic associations where relevant. The unique combination of functional importance, to protect and lubricate the eye, and cosmetic importance make management of eyelid lesions difficult. We describe a few of the diagnostic and treatment options that can be considered.
Solitary mastocytoma of the eyelid. A case report with special reference to the immunocytology of human tissue mast cells, and a review of the literature
Sebaceous carcinomas of the ocular adnexa: A clinicopathologic study of 104 cases, with five-year follow-up data
Anaplastic large cell lymphomas lack the expression of T-cell receptor molecules or molecules of proximal T-cell receptor signaling.
A case of symmetrical leukemia cutis on the eyelids complicated by B-cell chronic lymphocytic lymphoma
Merkel cell carcinoma of the eyelid review of the literature and report of patients with Merkel cell carcinoma showing spontaneous regression
Metastatic tumors to the oral and maxillofacial region: a retrospective study of 19 cases in West China and review of the Chinese and English literature
Leukemia cutis (involving chronic lymphocytic leukemia) within excisional specimens: a series of 6 cases
Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature
Spectrum of CD30+ lymphoid proliferations in the eyelid lymphomatoid papulosis, cutaneous anaplastic large cell lymphoma, and anaplastic large cell lymphoma
Dramatic effect of vitamin D supplementation and a gluten-free diet on bone mineral density in a patient with celiac disease
The differential diagnosis between primary cutaneous large B-cell lymphoma and cutaneous follicular lymphoma: prognostic and therapeutic implications
Carbon dioxide laser treatment for lentigo maligna: a retrospective review comparing 3 different treatment modalities
P75 nerve growth factor receptor as a useful marker to distinguish spindle cell melanoma from other spindle cell neoplasms of sun-damaged skin
Melanoma in situ treated successfully using imiquimod after nonclearance with surgery: review of the literature
Sebaceous neoplasms with mismatch repair protein expressions and the frequency of co-existing visceral tumors
Autoimmune Polyendocrine Syndromes
This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.