Malignancy Grade-Dependent Mapping of Metabolic Landscapes in Human Urothelial Bladder Cancer: Identification of Novel, Diagnostic, and Druggable Biomarkers

International Journal of Molecular Sciences
Aikaterini IliouDimitrios J Stravopodis

Abstract

Urothelial bladder cancer (UBC) is one of the cancers with the highest mortality rate and prevalence worldwide; however, the clinical management of the disease remains challenging. Metabolomics has emerged as a powerful tool with beneficial applications in cancer biology and thus can provide new insights on the underlying mechanisms of UBC progression and/or reveal novel diagnostic and therapeutic schemes. A collection of four human UBC cell lines that critically reflect the different malignancy grades of UBC was employed; RT4 (grade I), RT112 (grade II), T24 (grade III), and TCCSUP (grade IV). They were examined using Nuclear Magnetic Resonance, Mass Spectrometry, and advanced statistical approaches, with the goal of creating new metabolic profiles that are mechanistically associated with UBC progression toward metastasis. Distinct metabolic profiles were observed for each cell line group, with T24 (grade III) cells exhibiting the most abundant metabolite contents. AMP and creatine phosphate were highly increased in the T24 cell line compared to the RT4 (grade I) cell line, indicating the major energetic transformation to which UBC cells are being subjected during metastasis. Thymosin β4 and β10 were also profiled with grade-s...Continue Reading

References

Jul 2, 2004·Nature Reviews. Cancer·Julian L Griffin, John P Shockcor
Nov 2, 2004·Nature Reviews. Cancer·Robert A Gatenby, Robert J Gillies
Oct 30, 2007·Analytical Biochemistry·Huifeng WuMark R Viant
Oct 10, 2009·Nature Biotechnology·Jason W LocasaleMatthew G Vander Heiden
Oct 23, 2009·Journal of Cellular and Molecular Medicine·Gareth CatchpoleSteffen Weikert
May 15, 2010·Analytical Chemistry·Martin StrohalmVladimír Havlícek
Jul 6, 2010·Drug Discovery Today·Miroslava Cuperlović-CulfIan Chute
Oct 29, 2010·Nature·Shinichi YachidaChristine A Iacobuzio-Donahue
Feb 15, 2011·Genes & Development·Jessie Yanxiang GuoEileen White
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 19, 2011·BMC Bioinformatics·Xavier RobinMarkus Müller
Apr 22, 2011·Nature Reviews. Cancer·Willem H KoppenolChi V Dang
Jul 30, 2011·Molecular & Cellular Proteomics : MCP·Zhenzhen HuangWei Hang
Sep 6, 2011·Nature Cell Biology·Maria M Mihaylova, Reuben J Shaw
Dec 14, 2011·Journal of Proteome Research·Yu ChengWei Jia
Mar 23, 2012·Nature Reviews. Molecular Cell Biology·D Grahame HardieSimon A Hawley
Aug 11, 2012·European Urology·Maximilian BurgerYair Lotan
Nov 15, 2012·Clinical Chemistry·Omran Abu Aboud, Robert H Weiss
Jan 17, 2013·Cancer Investigation·Sirinapa SribenjaChangyi Chen
Feb 26, 2013·Electrophoresis·Zacarías LeónAgustín Lahoz
Apr 2, 2013·The Urologic Clinics of North America·Andrew C James, John L Gore
Sep 4, 2013·Molecular Carcinogenesis·Wei ZhengDorothy Teegarden
Nov 14, 2013·Journal of Proteome Research·Navneeta BansalSudhir Kumar Mandal
Dec 30, 2014·PloS One·Bryan WittmannRobert L Wolfert
Jan 21, 2015·Cell·Jia Min LooSohail F Tavazoie
Jan 31, 2015·Cell·William J Sullivan, Heather R Christofk
Mar 17, 2015·Nature Cell Biology·Lindsey K Boroughs, Ralph J DeBerardinis
Jan 26, 2016·International Journal of Cancer. Journal International Du Cancer·Daniela RodriguesMárcia Carvalho
Jul 8, 2016·Science Advances·Ralph J DeBerardinis, Navdeep S Chandel
Dec 16, 2016·Nature·Kathryn L HarperJulio A Aguirre-Ghiso
Dec 16, 2016·Nature·Hedayatollah HosseiniChristoph A Klein
Dec 21, 2016·Bioinformatics·Stefano CacciatoreDavid A MacIntyre
May 4, 2018·Nature Reviews. Clinical Oncology·Panagiotis J Vlachostergios, Bishoy M Faltas
Mar 17, 2019·International Journal of Molecular Sciences·Aikaterini F GiannopoulouDimitrios J Stravopodis
Mar 20, 2019·Molecular Cancer Research : MCR·Alessandro ValliAdrian L Harris
Jun 22, 2019·Metabolomics : Official Journal of the Metabolomic Society·Valentina L KouznetsovaIgor F Tsigelny
Oct 17, 2019·Experimental and Therapeutic Medicine·Bingwei WangGuosheng Yang
Dec 11, 2019·British Journal of Cancer·Lisa VettoreDaniel A Tennant

Citations

May 13, 2020·Cancers·Mikołaj WołącewiczPaulina Niedźwiedzka-Rystwej

Related Concepts

Biological Markers
Malignant Neoplasms
Diagnosis
Objective (Goal)
Microfilaments
Neoplasm Metastasis
Phosphocreatine
Mass Spectrometry
Thymosin
Cell Line, Tumor

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