Malignancy rates for Bethesda III subcategories in thyroid fine needle aspiration biopsy (FNAB)

Clinics
Leticia MoscaClaudio Roberto Cernea

Abstract

Most thyroid diseases are nodular and have been investigated using ultrasound-guided fine needle aspiration biopsy (FNAB), the reports of which are standardized by the Bethesda System. Bethesda category III represents a heterogeneous group in terms of lesion characteristics and the malignancy rates reported in the literature. The objective of the present study was to evaluate the differences in the malignancy rates among Bethesda III subcategories. Data from 1,479 patients who had thyroid surgery were reviewed. In total, 1,093 patients (89.6% female, mean age 52.7 (13-89) years) were included, and 386 patients were excluded. FNAB results (based on Bethesda Class) and histopathological results (benign or malignant) for coincident areas were collected. Bethesda III patients were subcategorized according to cytopathological characteristics (FLUS: follicular lesion of undetermined significance, Bethesda IIIA; AUS: atypia of undetermined significance, Bethesda IIIB). Data were correlated to obtain the malignancy rates for each Bethesda category and the newly defined subcategory. FNAB results for these patients were as follows: Bethesda I: 3.1%; Bethesda II: 18.6%; Bethesda III: 35.0%; Bethesda IV: 22.1%; Bethesda V: 4.1%; and Bethes...Continue Reading

References

Oct 23, 2009·American Journal of Clinical Pathology·Edmund S CibasUNKNOWN NCI Thyroid FNA State of the Science Conference
Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Constantine G A TheoharisDavid C Chhieng
Jun 1, 2010·Otolaryngologic Clinics of North America·Edmund S Cibas
Feb 26, 2013·The Journal of Clinical Endocrinology and Metabolism·Matthew T OlsonMartha A Zeiger
Mar 21, 2013·Diagnostic Cytopathology·Constantine TheoharisDavid Chhieng
Apr 13, 2013·International Journal of Health Sciences·Shagufta Tahir Mufti, Rihab Molah
Jul 6, 2013·Arquivos brasileiros de endocrinologia e metabologia·Pedro Weslley RosárioUNKNOWN Sociedade Brasileira de Endocrinologia e Metabologia

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Citations

Oct 25, 2020·Cytopathology : Official Journal of the British Society for Clinical Cytology·Saira FatimaArsalan Ahmed
Jan 14, 2022·Clinical and Experimental Medicine·Suleyman Hilmi AksoySelami Aydin

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Methods Mentioned

BETA
biopsy

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SPSS

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