Malignancy risk and characteristics of thyroid nodules with two consecutive results of atypia of undetermined significance or follicular lesion of undetermined significance on cytology

European Radiology
Vivian Y ParkHee Jung Moon

Abstract

To evaluate the malignancy risk and characteristics of thyroid nodules with two "Atypia of Undetermined Significance" or "Follicular Lesion of Undetermined Significance" (AUS/FLUS) results, and compare characteristics of malignancies with two AUS/FLUS results to those with one AUS/FLUS result. Of 441 thyroid nodules with initial AUS/FLUS results, 236 underwent repeat fine-needle-aspiration (FNA), with 58 obtaining repeated AUS/FLUS results. Thyroid Imaging Reporting and Data System (TIRADS) categories were assigned, and clinico-pathological characteristics were compared between benign and malignant nodules and between malignancies with two consecutive AUS/FLUS results and those with one AUS/FLUS result. Thirty-one percent (18/58) of nodules with two AUS/FLUS results and 58.1% (18/31) of confirmed nodules were malignant. Age, gender, nodule size, ultrasound features and TIRADS categories did not differ between benign and malignant nodules or between malignancies with one and two AUS/FLUS results. Malignancies with two AUS/FLUS results had a higher proportion of a follicular variant of papillary thyroid carcinoma (PTC) (46.7% vs. 13.6%, P = 0.009). Thyroid nodules with two AUS/FLUS results had a high malignancy risk of at least 3...Continue Reading

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Citations

Sep 3, 2016·Clinical Hemorheology and Microcirculation·Feng MaoShen Qu
Jan 5, 2018·Endocrine Reviews·Elizabeth J de KosterDennis Vriens
Jun 14, 2016·Journal of Pathology and Translational Medicine·Youngjin KangYang Seok Chae
Jul 18, 2017·Cytopathology : Official Journal of the British Society for Clinical Cytology·S TurkyilmazA Cinel
Jul 28, 2020·Journal of Clinical Medicine·Dorota Słowińska-KlenckaBożena Popowicz
Feb 9, 2021·Annals of Saudi Medicine·Aseel DoubiSaleh F Al-Dhahri
Jul 25, 2021·Journal of Clinical Medicine·Krzysztof KaliszewskiJerzy Rudnicki

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