Malignancy risk for the categories: Non-diagnostic, benign, atypical, suspicious, and malignant used in the categorization of endobronchial ultrasound guided-fine needle aspirates of pulmonary nodules

Diagnostic Cytopathology
Lester J LayfieldBen Witt

Abstract

Endobronchial ultrasound-guided fine-needle aspiration (EBUS-FNA) is frequently used for the workup of pulmonary nodules. While no universally accepted diagnostic classification exists, many cytopathologists use the categories: Non-diagnostic, benign, atypical, suspicious and malignant. Sensitivity and specificity for the EBUS technique have been documented, but little information is available for malignancy risk associated with these categories. Departments of Pathology records at the University of Utah and University of North Carolina, Chapel Hill were searched for EBUS-FNAs of pulmonary nodules. Cases with surgical follow-up were selected. Cytologic diagnosis and subsequent surgical diagnosis were correlated and malignancy risk calculated for each category. Sensitivity and specificity were calculated. 155 EBUS-FNAs with surgical follow-up were obtained. Risks of malignancy were: Non-diagnostic 40%, benign 24%, atypical 54%, suspicious for malignancy 82% and malignant 87%. Sensitivity and specificity were 81% and 84% respectively for surgically confirmed cytologic diagnoses when indeterminate categories were excluded. The diagnostic categories are associated with increasing risk of malignancy running from non-diagnostic to ma...Continue Reading

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Citations

May 26, 2016·Cytopathology : Official Journal of the British Society for Clinical Cytology·L J Layfield
May 26, 2016·Cytopathology : Official Journal of the British Society for Clinical Cytology·A Chandra
Oct 4, 2018·Cancer Cytopathology·Heba W Z Khella, George M Yousef

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