Malignant Adenomyoepithelioma of the Breast and Responsiveness to Eribulin

Journal of breast cancer
Suee LeeHyo-Jin Kim

Abstract

Adenomyoepithelioma (AME) of the breast is an uncommon tumor characterized by its dual differentiation into luminal cells and myoepithelial cells. In most cases these tumors have a benign clinical course, but distant metastases have been reported. We present the case of a 51-year-old woman diagnosed with malignant AME. The patient underwent a right modified radical mastectomy, and pathological examination confirmed the diagnosis of malignant AME. Ten months after the operation, multiple hepatic, pleural, and abdominal wall metastases were detected. A number of palliative chemotherapeutic agents were tried, including anthracycline and taxanes. However, the disease continued to progress, and superior vena cava syndrome developed as a result of direct tumor invasion. The patient received salvage eribulin monotherapy. After two cycles of this treatment, her clinical symptoms were ameliorated, and a computed tomography scan showed a partial response. Eribulin chemotherapy was thus effective in treating malignant AME in this case.

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Citations

Aug 5, 2016·Journal of Cardiothoracic Surgery·Agnieszka KorolczukTomasz Koncewicz
May 2, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paula S GinterJuan Miguel Mosquera
May 31, 2020·Surgical Case Reports·Kazuki MoroHaruhiko Makino
Feb 18, 2021·Medicine·Zhihao ZhangMing Yang

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Methods Mentioned

BETA
biopsy
dissection

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