Malignant amelanotic melanoma behind the left eye in a female Crj:CD(SD)IGS rat: a case report

Veterinary Pathology
T KurotakiM Tsuchitani

Abstract

A tumor behind the left eye in a female Crj:CD(SD)IGS rat was investigated histopathologically, immunohistopathologically, and electron microscopically. The tumor invaded and destroyed orbital tissues and bones. It consisted of various tumor cells; namely, spindle-shaped, epithelioid, anaplastic melanoma cells, and had prominent eosinophilic cytoplasm and nuclei with a greater variation in size. Immunohistochemically, almost all of the tumor cells were positive for antimelanoma, PNL2 antibody. Ultrastructurally, the tumor cells were rich in small vesicles containing fine granules and filamentous structures. This is the first report describing an amelanotic melanoma in the head of an albino rat.

References

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Jan 1, 1973·Archiv Für Dermatologische Forschung·A BomirskiF Pautsch
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May 1, 1993·Veterinary Pathology·K Yoshitomi, G A Boorman
May 1, 1996·Archives of Ophthalmology·P De PotterJ L Lipkowitz

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Citations

Feb 10, 2012·Journal of Toxicologic Pathology·Tomoya OnozatoJunji Kuroda
Nov 5, 2011·Veterinary Ophthalmology·Leandro LimaIngeborg Langohr
May 13, 2010·Veterinary Pathology·P M ZerfasM A Eckhaus
Mar 1, 2011·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Amanda Guthrie, Thomas deMaar

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