PMID: 6985528Dec 5, 1980Paper

Malignant and benign lymphomas: histologic classification and immunomorphologic studies. Results of 838 cases

Wiener klinische Wochenschrift
T Radaszkiewicz

Abstract

800 malignant (22.9% Hodgkin's, 77.1% non-Hodgkin's) lymphomas, 22 cases of lymphogranulomatosis X and 16 pseudolymphomas were investigated by histology and immunomorphology. Age- and sex-distribution, localization as well as intracytoplasmic immunoglobulins (Ig) in tumour cells were evaluated. Hodgkin's lymphomas were classified according to Lukes (1971), the non-Hodgkin's lymphomas (NHL) according to the Kiel-classification. Among NHL of low grade malignancy the most common type was chronic lymphocytic leukaemia (CLL) (18%), among the NHL of high grade malignancy the immunoblastic lymphomas (IB) (13%). In IB 5 cases of T-cell type of IB were be identified. 8 cases were classified as "histiocytic" reticulosarcomas. Immunomorphology performed on routinely formalin-fixed, paraffin-embedded tissue sections showed a clear-cut difference between CLL and immunocytic lymphomas (IC): In all IC "monoclonal" Ig could be detected in lymphoplasmacytoid and plasma cells. The most common Ig was of the IgM/K type. 4 IC were turned out as "biclonal" ML detected by the double immunofluorescence. In IB lymphomas less than 50% contained intracytoplasmic Ig mainly of the IgM/K type. In Hodgkin's- and Sternberg cells sometimes IgG, K, lambda and a...Continue Reading

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