Malignant and nonmalignant gene signatures in squamous head and neck cancer.

Journal of Oncology
Maria J WorshamVanessa G Schweitzer

Abstract

Genetic events specific to the pathogenesis of malignancy can offer clues to the tumorigenesis process. The objective of this study was to identify gene alterations that differentiate tumor and nontumor lesions in squamous head and neck cancer (HNSCC). DNA from 220 primary HNSCC with concurrently present tumor and nontumor lesions from the same patient was interrogated for genomic alterations of loss or gain of copy. Conditional logistic regression dealt with tumor and non-tumor records within a patient. Of 113 genes, 53 had univariate effects (P < 0.01), of which 16 genes remained in the multivariable model with P < 0.01. The model had a C-index (ROC) of 0.93. Loss of CDKN2B and gain of BCL6, FGF3, and PTP4A3 predicted tumor. Loss of BAK1 and CCND1 and gain of STCH predicted nontumor. This highly powered model assigned alterations in 16 genes specific for malignant versus nonmalignant lesions, supporting their contribution to the pathogenesis of HNSCC as well as their potential utility as relevant targets for further evaluation as markers of early detection and progression.

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Citations

Oct 12, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Saraswathy SeemaRajendra P Tripathi
Jul 4, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liancheng ZhuBei Lin
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Song GaoBei Lin
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Nov 9, 2018·International Journal of Molecular Sciences·James J PhelanJacintha O'Sullivan
Jan 11, 2013·The Journal of Biological Chemistry·Jun-Seok BaeKyungpyo Park

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Methods Mentioned

BETA
chromosomal aberrations
biopsy
Assay
PCR

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