Malignant basomelanocytic tumor manifesting as metastatic melanoma

The American Journal of Surgical Pathology
Lori A EricksonMark R Pittelkow

Abstract

We report a case of an unusual basomelanocytic tumor from the scalp of a 56-year-old man. A 56-year-old white man presented with a scalp lesion that was biopsied and interpreted as a basal cell carcinoma. Fourteen months later, metastatic melanoma was discovered in a cervical lymph node and the liver. A subsequent biopsy from the area of the previously biopsied basal cell carcinoma of the scalp showed an invasive malignant melanoma. Immunohistochemical stains performed on the original scalp specimen showed biphasic immunohistochemical profile. A population of neoplastic cells was strongly positive for the melanocytic markers Melan-A, HMB-45, and tyrosinase and showed weak focal immunoreactivity for S-100. A second population of cells was strongly immunoreactive for keratin (wide-spectrum polyclonal antibody) and BerEp4. To our knowledge, this is the first description of a malignant basomelanocytic tumor complicated by metastatic melanoma.

References

Jun 1, 1984·The American Journal of Dermatopathology·H KerlK Holubar
Oct 1, 1984·The American Journal of Dermatopathology·V J Rosen
Oct 1, 1982·British Journal of Plastic Surgery·M F MuhlemannJ C Briggs
Jul 1, 1995·Histopathology·K Hara, S Kamiya
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·M AkiyamaK Nakamura
Jun 1, 1997·The American Journal of Dermatopathology·A Burkhalter, W L White
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·G E PiérardC Piérard-Franchimont
Aug 1, 1997·The Australasian Journal of Dermatology·S Kossard, D Cook
Oct 12, 2000·Journal of Cutaneous Pathology·R T CutlanT M Chesney
Feb 15, 2001·The American Journal of Dermatopathology·S R FlorellJ W Gerwels

❮ Previous
Next ❯

Citations

Dec 7, 2005·The American Journal of Surgical Pathology·Klaus J BusamAshfaq A Marghoob
Sep 25, 2007·The American Journal of Dermatopathology·Elizabeth K Satter
Jun 23, 2009·The American Journal of Dermatopathology·Niamh LeonardJ Eduardo Calonje
Jul 11, 2009·The American Journal of Dermatopathology·Mariya MitevaPaolo Romanelli
Jan 22, 2011·The American Journal of Dermatopathology·Jamie ZussmanScott W Binder
Mar 19, 2013·The American Journal of Dermatopathology·Africa JuárezLuis Requena
Oct 11, 2011·American Journal of Ophthalmology·Maria Kirzhner, Frederick A Jakobiec
Mar 14, 2007·Mayo Clinic Proceedings·Svetomir N MarkovicUNKNOWN Melanoma Study Group of the Mayo Clinic Cancer Center
Aug 19, 2007·Journal of Cutaneous Pathology·Markus Braun-Falco
Aug 30, 2008·Journal of Cutaneous Pathology·Elizabeth K SatterDirk M Elston
Sep 11, 2007·Histopathology·S S Banerjee, B Eyden
Jun 21, 2007·The British Journal of Dermatology·S M TaibjeeR A Carr
Aug 1, 2006·Pathology, Research and Practice·Giovanni PapaMichele Pascone
Jul 26, 2015·Journal of the American Academy of Dermatology·Sapna M AminPedram Gerami
Apr 10, 2007·Mayo Clinic Proceedings·Svetomir N MarkovicUNKNOWN Melanoma Study Group of Mayo Clinic Cancer Center
Jul 20, 2018·The American Journal of Dermatopathology·Carlo CotaLorenzo Cerroni
Mar 21, 2020·The American Journal of Dermatopathology·Yanqing Wang, Ying Guo
Jul 28, 2020·Journal of Cutaneous Pathology·Hana Paladichuk, L Brent Talbott
Jun 3, 2014·The American Journal of Dermatopathology·George JourSeth Rosenthal
Apr 23, 2014·The American Journal of Dermatopathology·Megan Goeser, Dominick J DiMaio
Jan 6, 2016·The American Journal of Dermatopathology·Nima Mesbah ArdakaniBenjamin A Wood
Sep 30, 2020·Journal of Cutaneous Pathology·Manuel Pérez-PérezJuan J Ríos-Martín

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.