PMID: 8798322May 1, 1996Paper

Malignant degeneration of mature cystic teratomas

The Australian & New Zealand Journal of Obstetrics & Gynaecology
C G ZorluO Gökmen

Abstract

Malignant transformation of benign cystic teratoma is rare and the most common malignancy is squamous cell carcinoma. The diagnosis is rarely made preoperatively and the prognosis is usually poor. We report 4 cases with dermoid cysts showing malignant transformation, 3 with squamous carcinoma and 1 with adenocarcinoma. The patients were within the reproductive age and underwent surgical intervention with intraoperative evaluation. Frozen section identified 2 cases with malignant transformation and staging laparotomy was performed at the initial laparotomy. One of the remaining underwent reoperation following a pregnancy termination and the other refused further surgery. None had metastases and/or capsule invasion. One had tumour rupture during excision and received combined chemotherapy following surgery. Three of the patients remain well and 1 is lost to follow-up.

References

Dec 1, 1989·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·W A Christopherson, R B Councell

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Citations

May 30, 2006·Journal of Clinical Pathology·M A den BakkerP C Ewing-Graham
Dec 4, 2010·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·I LataifehS Barahmeh
Jan 15, 2004·Pathology International·Miki Kushima
Jun 18, 2004·Journal of Korean Medical Science·Myong Cheol LimChu Yeop Huh
Dec 2, 2015·Obstetrics & Gynecology Science·Chan-Hong ParkYong-Il Ji
Aug 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S TangjitgamolS Jesadapatarakul

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