Malignant dermal cylindromas. Do they exist? A morphological and immunohistochemical study and review of the literature.

Pathology
P V Iyer, A S Leong

Abstract

Malignant dermal cylindromas are very rare. We present a case of multiple cylindromas of the scalp with metastasis to a cervical lymph node. The morphology of the tumour was unusual in that it contained eccrine spiradenoma-like areas and foci of squamous differentiation with keratin formation. The immunohistochemical phenotype of the eccrine spiradenoma-like areas and the metastatic tumour was similar, but different from the areas of typical cylindroma. Although alleged "malignant" cylindromas have been reported, none have been described to have metastasized, whereas metastatic eccrine spiradenoma is well-documented. We reiterate that overlaps between dermal cylindroma and eccrine spiradenoma are more common than has been documented. In the rare event of metastases, it is the eccrine spiradenomatous component that is metastatic. We contend that there is no evidence that pure dermal cylindromas have metastasized.

References

May 1, 1979·Cancer·H L EvansR K Winkelmann
Apr 1, 1987·Journal of Cutaneous Pathology·P E SwansonM R Wick
Apr 1, 1987·The American Journal of Dermatopathology·M R WickM R Pittelkow
Apr 1, 1986·The British Journal of Dermatology·D W Cotton
Oct 1, 1984·Journal of Cutaneous Pathology·N S Penneys
Jul 1, 1980·Histopathology·R V Dissanayake, R Salm
Apr 1, 1982·Archives of Dermatology·D K GoetteV R Fowler
Jul 1, 1984·The British Journal of Dermatology·D W Cotton, S G Braye
Aug 1, 1984·The British Journal of Dermatology·A L KariniemiL C Andersson

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Citations

Nov 13, 2001·The British Journal of Dermatology·B K DuraniW Hartschuh
Jan 29, 2005·The American Journal of Dermatopathology·Vincenzo De FrancescoPasquale Patrone
Dec 29, 2007·Journal of Dermatological Case Reports·Justyna SicinskaLidia Rudnicka
May 20, 2014·Annales de dermatologie et de vénéréologie·A RichardA Dompmartin
May 25, 2013·International Journal of Surgery Case Reports·Gokhan Giray AkgulMehmet Ali Gulcelik
Sep 1, 1993·Cancer·A L GerretsenW A van Vloten
Aug 7, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Stephen C CowinMohammed Benalla
Sep 8, 2016·Cancers of the Head & Neck·Krista Roberta VerhoeftVivian Wai Yan Lui

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