Malignant disease in pregnancy

Journal of Perinatal Medicine
H R Barber

Abstract

Cancers in pregnancy are uncommon but do occur with an average frequency of 1 in 1,000 births. This gives rise to opposing emotional reactions in these women: they are happy they are pregnant, but usually devastated when they hear they have cancer. The major reasons for suspecting that pregnancy adversely affects the clinical course of cancer is the immunologic tolerance that characterizes both conditions. It has been pointed out that normal pregnancy and cancer are the only two biologic conditions in which the antigenic tissues is tolerated by a seemingly intact system. It may be stated that the mechanisms that insure the survival of fetus during pregnancy presumably also favors the progress of the neoplasia. Management requires individualization with careful thought as whether termination is necessary or whether continuing with the pregnancy is possible prior to definitive treatment. The physician's aim must be to cure the cancer and deliver live, healthy infants. This is one question when a joint decision is probably best reached among the obstetrician, surgical and medical oncologists and other disciplines. The life-threatening cancer should be managed both for the diagnosis and treatment as in the non-pregnant state. An ea...Continue Reading

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Citations

Dec 12, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·G PomaraC Selli
Aug 1, 2007·Journal of Medical Ethics·Shalini PatniSteve Edwards
Nov 18, 2014·Case Reports in Obstetrics and Gynecology·Sung-Hee KimWon-Ho Edward Park
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