Malignant epithelioid mesothelioma: anti-mesothelial marker expression correlates with histological pattern

Histopathology
R L AttanoosA R Gibbs

Abstract

Malignant epithelioid mesothelioma shows marked cytoarchitectural diversity. The aim of the study was to evaluate how immunoreactivity with mesothelial markers related to histological pattern. Ninety-two cases of malignant epithelioid mesothelioma (60 pleural, 32 peritoneal) were examined and classified as exhibiting tubulopapillary, adenomatoid, solid, small cell or pleomorphic patterns. All cases were immunohistochemically stained with thrombomodulin, calretinin, CD44H, and cytokeratin 5/6. Cases of malignant mesothelioma exhibited a number of different histological forms. Immunohistochemical expression of each mesothelial marker tested was not homogeneous across different histological patterns of malignant epithelioid mesothelioma, even within the same tumour section. Calretinin (with nuclear expression) was identified to show the highest overall sensitivity and lowest range variation in staining (67% sensitivity in small cell areas to 100% expression in pleomorphic areas). Cytokeratin 5/6 and thrombomodulin yielded similar overall sensitivity. Thrombomodulin appeared to demonstrate higher sensitivity for small cell variant tumour (83% sensitivity). A notable advantage with cytokeratin 5/6 was that expression was more diffus...Continue Reading

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Citations

Dec 7, 2005·The American Journal of Surgical Pathology·Alison M WinstanleyMargaret C Parkinson
Apr 6, 2004·Environmental Health Perspectives·Rodolfo FonteStefano M Candura
Mar 1, 2012·Archives of Pathology & Laboratory Medicine·Pier-Giacomo BettaSara Orecchia
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Apr 22, 2009·Toxicologic Pathology·Paul HowroydJerry Hardisty
May 26, 2018·The Journal of Veterinary Medical Science·Nguyen V SonHiroyuki Nakayama

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