Malignant Extra-Gastrointestinal Stromal Tumor of the Mesentery

The Surgery Journal
Prakash K SasmalBikram Rout

Abstract

Gastrointestinal stromal tumors (GISTs), the commonest mesenchymal tumors of gastrointestinal tract are often described to take origin from the interstitial cells of Cajal (ICC) or its precursor cells. Rarely these tumors do arise in structures other than the alimentary tract like omentum, mesentery, retroperitoneum, etc., of varying malignant potential and are known as extra-gastrointestinal stromal tumors (eGISTs). This is a case report of a 70-year-old female with multicentric malignant eGISTs arising in the mesentery of ileum. On laparotomy, a large mass of 20 × 15 cm was found in the small bowel mesentery without involvement of the adjacent ileum, with multiple other small nodules resembling lymph nodes, present adjacent to it. Histopathological study of the excised lump, confirmed the mass to be malignant eGIST without involvement of the adjacent ileum, with cluster differentiation (CD)117 positive and of high-risk stratification. The mesenteric nodule was confirmed on histopathology to be malignant eGIST, similar to that of that of the primary, without any lymphoid tissue. Adjuvant imatinib mesylate treatment was started immediately postoperation with the patient doing well at 1 year of follow-up. We report this case, du...Continue Reading

Citations

Dec 10, 2020·Annals of Medicine and Surgery·Gregorio Arellano-GutiérrezEdwin Leopoldo Maldonado-García
Aug 15, 2020·Radiology Case Reports·Thai Thi My Hanh NguyenThanh Thao Nguyen
Nov 16, 2021·Scandinavian Journal of Gastroenterology·Jing-Jing GuoZhi-Kui Chen

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