PMID: 8952034Nov 1, 1996Paper

Malignant fibrous histiocytoma and malignant histiocytosis in the dog--convergent or divergent phenotypic differentiation?

Veterinary Pathology
R L Kerlin, M J Hendrick

Abstract

Malignant fibrous histiocytoma (MFH) and malignant histiocytosis (MH) are neoplasms with different histologic appearances and consequently a different putative cell of origin. Recently, the biopsy and necropsy services at the University of Pennsylvania have seen many canine soft tissue sarcomas that have the gross and histologic appearances of both MH and MFH within the same animal. A retrospective histologic evaluation of 263 cases diagnosed originally as either MH or MFH reclassified these neoplasms into 77 cases that were exclusively MH, 110 cases exclusively MFH, and 76 cases with features of both MH and MFH. Age, sex, breed predispositions, and distribution of lesions in organs were remarkably similar between the two categories. The hybrid neoplasms containing MH-like and MFH-like regions may be the result of divergent or convergent phenotypic differentiation.

Citations

Feb 5, 2009·Journal of Veterinary Internal Medicine·L TziporyW Vernau
Jun 6, 2013·ISRN Veterinary Science·Jane M Dobson
Jan 13, 2005·Veterinary Ophthalmology·Mary E LassalineGary W Ellison
Jan 3, 2013·Veterinary Immunology and Immunopathology·V QeskaA Beineke
May 21, 2009·Veterinary and Comparative Oncology·J DobsonJ L N Wood
Nov 21, 2007·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Ryan M SchultzPeter F Moore
Jun 1, 2006·Veterinary and Comparative Oncology·J FidelB Kaser-Hotz
Jul 18, 2003·The Journal of Veterinary Medical Science·Hiroki SakaiToshiaki Masegi
Jan 11, 2007·The Journal of Veterinary Medical Science·Daigo AzakamiKenichiro Ono
Feb 24, 2001·The Journal of Veterinary Medical Science·T AnjikiK Kadota
May 11, 2016·Journal of Veterinary Internal Medicine·A Ruple, P S Morley
May 26, 2017·The Journal of Small Animal Practice·J A LenzC M Cannon
Jul 10, 2002·Veterinary Pathology·L E CraigJ D Ferracone
Jul 10, 2002·Veterinary Pathology·V K Affolter, P F Moore
Nov 24, 1999·Veterinary Pathology·W L Spangler, P H Kass
May 25, 2002·Veterinary Clinical Pathology·Douglas J. Weiss
Jan 11, 2020·Journal of Veterinary Internal Medicine·Izumi ToyodaPeter J Dickinson
Apr 30, 2020·Veterinary Pathology·Christof A BertramMatti Kiupel
Dec 21, 2004·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Robert Cruz-ArámbuloBarbara Powers
Apr 17, 2002·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Sammy RamirezIan D Robertson
Aug 25, 2004·Journal of the American Veterinary Medical Association·Ravinder S Dhaliwal, Ann L Reed
Nov 20, 2019·The Journal of Small Animal Practice·J M Dobson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.