Malignant fibrous histiocytoma of bone: analysis of genomic imbalances by comparative genomic hybridisation and C-MYC expression by immunohistochemistry

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Maija TarkkanenSakari Knuutila

Abstract

Malignant fibrous histiocytoma (MFH) of bone is a rare, highly malignant tumour. As very little is known about its genetic alterations, 26 bone MFHs were analysed by comparative genomic hybridisation (CGH). Twenty-three tumours (89%) had DNA sequence copy number changes (mean, 7.2 changes per sample). Gains were more frequent than losses (gains:losses=2.5:1). Minimal common regions for the most frequent gains were 8q21.3-qter (35%), 9q32-qter (35%), 7q22-q31 (35%), 1q21-q23 (31%), 7p12-pter (31%), 7cen-q11.2 (31%) and 15q21 (31%). Minimal common regions for the most frequent losses were 13q21-q22 (42%) and 18q12-q22 (27%). High-level amplifications were detected in 8 out of the 26 tumours (31%). The only recurrent amplifications, 1q21-q23 and 8q21.2-q22, were present in two samples (8%). As copy number increase at 8q24 (the locus of C-MYC) was frequent, the expression of C-MYC was studied by immunohistochemistry. Increased levels of c-myc protein were detected in 7 out of 21 tumours studied (33%). 81% of the samples studied both by CGH and immunohistochemistry showed concordant results. Furthermore, the findings of the present study were compared to previous publications on osteosarcoma, soft tissue MFH and fibrosarcoma of bone...Continue Reading

References

Jun 1, 1992·Cancer Genetics and Cytogenetics·C OrndalF Mitelman
Jan 1, 1991·Genes, Chromosomes & Cancer·B JohanssonF Mitelman
Sep 1, 1989·Genes, Chromosomes & Cancer·N MandahlF Mitelman
Jan 1, 1988·Cancer Genetics and Cytogenetics·N MandahlF Mitelman
Aug 1, 1995·Cancer Genetics and Cytogenetics·M NilbertN Mandahl
Jan 1, 1994·Oncology·C BarriosA Kreicbergs
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·Y UedaA Roessner
Apr 1, 1997·Cancer Genetics and Cytogenetics·T A WalterD K Hossfeld
Oct 27, 1998·Pathology International·T FukudaT Nakamura
Mar 30, 1999·International Journal of Cancer. Journal International Du Cancer·M TarkkanenS Knuutila
Apr 5, 2000·Cancer Genetics and Cytogenetics·A SimonsR Suijkerbuijk
Jun 22, 2000·Genes, Chromosomes & Cancer·C StockP F Ambros
Nov 7, 2003·Genes, Chromosomes & Cancer·Ching C LauPulivarthi H Rao

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Citations

May 21, 2014·PloS One·Alessandra De RobertisMassimiliano Salerno
Feb 4, 2010·Annals of Diagnostic Pathology·Hye Sook MinJae Y Ro
Nov 27, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jyoji YamateJonathan LaMarre
Jul 26, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Takashi KoteraJyoji Yamate
Dec 17, 2009·The American Journal of Pathology·Johanna MannerPhilipp Ströbel
Nov 19, 2009·Acta Orthopaedica. Supplementum·Thor AlvegårdAnders Rydholm
Sep 1, 2008·Expert Review of Endocrinology & Metabolism·Shonali DebSurinder K Batra
May 30, 2021·Seminars in Diagnostic Pathology·Iva Brčić, Andrew E Rosenberg

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