PMID: 8600111Mar 15, 1996Paper

Malignant fibrous histiocytoma: outcome and prognostic factors following conservation surgery and radiotherapy

International Journal of Radiation Oncology, Biology, Physics
G K ZagarsA Pollack

Abstract

Malignant fibrous histiocytoma is the most common type of soft tissue sarcoma. This communication presents an analysis of outcome and prognostic factors based on a retrospective review of patients with this disease treated by conservation surgery and radiotherapy. From 1966 to 1991, 271 consecutive patients with malignant fibrous histiocytoma were treated with conservation surgery and radiotherapy. The outcome with local control, metastatic relapse, and survival as end points was evaluated by univariate and multivariate statistics to delineate independently significant prognostic factors. Postoperative radiation at a mean dose of 62.8 Gy was used in 195 patients and preoperative radiation at a mean dose of 50 Gy was used in 76 patients. At a median follow-up of 7.3 years, 123 patients (45%) developed disease relapse at some site. Fifty-seven (21%) developed local recurrence leading to an actuarial local relapse rate of 26% at 10 years, 83 (31%) developed metastatic relapse for a 10-year actuarial metastatic rate of 33%, and the 5-, 10-, and 15-year survival rates were 68, 60, and 46%, respectively. For local control, prior local recurrence (in 53 patients) was identified as an adverse factor, yielding a 10-year recurrence rate ...Continue Reading

References

Apr 1, 1977·Cancer·S W Weiss, F M Enzinger
Jun 1, 1978·Cancer·S W Weiss, F M Enzinger
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·H M FagundesN A Kucik
Mar 1, 1991·International Journal of Radiation Oncology, Biology, Physics·L S GemerR Hassanein
Dec 1, 1989·Acta Orthopaedica Scandinavica·A AlhoB Stener
Apr 1, 1988·International Journal of Radiation Oncology, Biology, Physics·H T BarkleyG K Zagars
Jul 1, 1986·Cancer·D A PotterS A Rosenberg
Mar 1, 1981·International Journal of Radiation Oncology, Biology, Physics·M T ReaganN Rangala
Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histology·H J Leu, M Makek
Jan 1, 1980·Journal of Surgical Oncology·B SanyalN N Khanna
Nov 15, 2001·International Journal of Clinical Oncology·A FukushimaS Nakamura
Nov 1, 1964·Cancer·J E O'BRIEN, A P STOUT

❮ Previous
Next ❯

Citations

Jul 19, 2002·Cancer·Darren J LittleRobert S Benjamin
Apr 11, 2012·Archives of Orthopaedic and Trauma Surgery·Kontogeorgakos A VasileiosBrian E Brigman
Jan 7, 2011·International Journal of Clinical Oncology·Seung-Yeon ChoiDuk-Soo Bae
Jun 15, 2005·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Yukinori SakaoTsuyoshi Itoh
Apr 27, 2010·Journal of Gastrointestinal Cancer·Nikolaos S SalemisEfstathios Tsohataridis
Sep 25, 2001·International Journal of Radiation Oncology, Biology, Physics·M D CallisterG K Zagars
Apr 8, 1998·International Journal of Radiation Oncology, Biology, Physics·M T BalloA Pollack
Nov 11, 1999·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·J Agapito
Feb 3, 2007·Taiwanese Journal of Obstetrics & Gynecology·Hung-Wen SuSzu-Yuan Chou
Feb 15, 2000·International Urology and Nephrology·D RépássyP Hazslinszky
Nov 2, 2002·BJU International·B KhoubehiO Karim
Feb 2, 2002·American Journal of Clinical Oncology·Nora JanjanMatthew Ballo
Jun 1, 2002·American Journal of Clinical Oncology·Peter F OrioTony Y Eng
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T U K DilekE Tok
Apr 27, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Krishna B Sharma
Feb 25, 2005·AJR. American Journal of Roentgenology·Paras LakhaniPaul J Zhang
Jan 5, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·John R Goldblum
Oct 24, 2000·Ryōikibetsu shōkōgun shirīzu·O Tachibana
Jan 26, 2013·The Kaohsiung Journal of Medical Sciences·Shuji SuzukiAkimichi Morita
Sep 8, 2007·Annals of Vascular Surgery·Gregory S BarronRobert S Kirsner
Apr 22, 2006·ANZ Journal of Surgery·Ian C DickinsonPeter Steadman
Jun 1, 2006·Veterinary and Comparative Oncology·J FidelB Kaser-Hotz
Jul 15, 2011·Journal of Cutaneous Pathology·Justin P BandinoDonald J Grande
Oct 27, 2011·Case Reports in Medicine·Anastasios KatsourakisEfthimios Chatzitheoklitos
Feb 27, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Takashi AsahiShunro Endo
Sep 1, 2014·Biochimica Et Biophysica Acta·Kazutaka KikutaTadashi Kondo
Aug 27, 2016·Case Reports in Surgery·Arash MoradiKhashayar Atqiaee
Nov 3, 2016·Veterinary Ophthalmology·Elizabeth CurtoBrian C Gilger
Mar 22, 2005·Surgical Oncology·Vijay P Khatri, James E Goodnight
Feb 21, 2008·Journal of Surgical Oncology·Alessandra F Nascimento, Chandrajit P Raut
Oct 4, 2006·Clinical Orthopaedics and Related Research·Lawrence R MenendezAlexander N Fedenko
Jan 18, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sharon W Weiss
Aug 21, 2019·World Journal of Surgical Oncology·Sanja PleštinaMarko Jakopović
Dec 13, 2006·The Journal of Bone and Joint Surgery. British Volume·J IssakovO Merimsky
Jun 6, 2019·BMC Urology·Forough EbrahimtabarMohammad Mehdi Darzi
Sep 18, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·S K VinodJ Fletcher
May 23, 2018·Skeletal Radiology·Nisreen S EzuddinTy K Subhawong
Jun 16, 2017·Stomatologii︠a︡·E G MatyakinSh R Gvetadze

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.