Abstract
Three dogs (two Rottweilers and a Flat-coated retriever) showed various neurological signs, including apathy, depression, circling, a partial decrease in functions associated with cranial nerves, seizures, hyperaesthesia, proprioceptive deficits, and increased spinal reflexes. In all three cases, necropsy revealed a solid, distinct, white mass in the brain and multiple, poorly demarcated, firm nodular proliferations in the lung; in one case the liver was also affected. Histopathological examination showed loosely aggregated, pleomorphic cells, with abundant eosinophilic cytoplasm. The neoplastic cells sometimes contained vacuoles or phagocytized cells. Binucleated and multinucleated giant cells, and mitotic figures, were common. Immunohistochemically, the tumour cells reacted strongly for lysozyme and vimentin, but there was no reaction for S-100 protein, cytokeratin, CD3 or CD79a. The histological and immunohistochemical examinations indicated a histiocytic origin of the tumour cells and malignant histiocytosis was therefore diagnosed.
References
May 1, 1993·Veterinary Pathology·D W HaydenJ C Manivel
Jun 22, 1999·Journal of Comparative Pathology·A M Chandra, P E Ginn
Mar 31, 2001·Veterinary Pathology·K UchidaS Tateyama
Jul 10, 2002·Veterinary Pathology·V K Affolter, P F Moore
Jan 8, 2004·The Journal of Veterinary Medical Science·Mari SuzukiSusumu Tateyama
Nov 10, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·P FantC Masserdotti
Citations
Jun 7, 2008·Veterinary Clinical Pathology·Robin W AllisonWilliam Vernau
Feb 22, 2008·Journal of Veterinary Internal Medicine·J M SnyderT J Van Winkle
Feb 5, 2009·Journal of Veterinary Internal Medicine·L TziporyW Vernau
Feb 26, 2015·Journal of Veterinary Internal Medicine·C L MarianiE MacKillop
Apr 30, 2009·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Shinji TamuraKazuyuki Uchida
May 13, 2011·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Erik R WisnerRobert J Higgins
Aug 13, 2011·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Steven TsaiAmy Sato
Jan 3, 2014·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Amanda TaylorBrian Porter
Mar 21, 2015·The Veterinary Journal·R Timothy Bentley
Dec 17, 2015·The Journal of Veterinary Medical Science·Atigan ThongtharbHiroyuki Nakayama
Mar 24, 2017·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Masae WadaMichio Fujita
Nov 6, 2009·The Journal of Veterinary Medical Science·Byeong-Teck KangHee-Myung Park
Jun 1, 2012·Toxicologic Pathology·Wolfgang KaufmannRobert Sills
Jan 11, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Tetsuya IdeHiroyuki Nakayama
Jan 11, 2020·Journal of Veterinary Internal Medicine·Izumi ToyodaPeter J Dickinson
Jun 2, 2009·The Veterinary Record·F M MolenaarB A Summers