Malignant insulinoma: permanent hepatic artery embolization of liver metastases--preliminary results

Cardiovascular and Interventional Radiology
F W WinkelbauerJ Lammer

Abstract

To evaluate permanent hepatic artery embolization of liver metastases of malignant insulinoma as a therapeutic procedure. Three female patients had persistent severe hypoglycemia after distal pancreatectomy because of a malignant insulinoma. Computed tomography (CT) and CT-portography (CTAP) were used for tumor assessment and follow-up and demonstrated multiple hypervascular metastases 0.5-3 cm in diameter in both lobes of the liver. Unilobar sequential transcatheter embolization of the hepatic artery was performed with an interval of 1-2 months between the procedures. Permanent occlusion was achieved by using a mixture of n-butyl-2-cyanoacrylate and ethiodized oil as an embolizing agent. In all patients, embolization of the hepatic artery was technically feasible and complete occlusion could be obtained. In two patients, collaterals originating from the right inferior phrenic artery were embolized superselectively 3 months after bilobar embolization. CTAP at that time revealed marked decrease in tumor size of more than 50%. All patients responded to the treatment as confirmed by normalization of measurable hormone levels, glucose levels, and disappearance of symptoms. Two patients are still alive after 24 and 31 months from th...Continue Reading

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Citations

Feb 3, 2009·Cardiovascular and Interventional Radiology·Melpomeni PeppaDimitrios Hadjidakis
Sep 3, 2013·Annales d'endocrinologie·Eric BaudinUNKNOWN Groupe d’étude des tumeurs endocrines
Jun 4, 2014·Japanese Journal of Radiology·Yoshito TakeuchiUNKNOWN Committee of Practice Guidelines of the Japanese Society of Interventional Radiology
Aug 5, 2004·Wiener klinische Wochenschrift·Klaus KaczirekBruno Niederle
May 27, 2014·La Presse médicale·Eric BaudinUNKNOWN pour la Société française d’endocrinologie et le Groupe d’étude des tumeurs endocrines
Sep 15, 2016·Journal of Endocrinological Investigation·M V DaviUNKNOWN NIKE Group
May 10, 2005·World Journal of Surgery·Achim StarkePeter Goretzki
Jun 7, 2005·Cancer·Boaz HirshbergPhillip Gorden
Dec 14, 2018·Cardiovascular and Interventional Radiology·Shunsuke SugawaraYoshitaka Inaba

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