Malignant lesions in the ventral prostate of alloxan-induced diabetic rats.

International Journal of Experimental Pathology
Daniele Lisboa RibeiroRejane M Goes

Abstract

The aim of this study was to evaluate the changes caused by chronic diabetes in the rat ventral prostate and to establish a correlation between diabetes and the development of prostatic lesions. Male rats received alloxan (42 mg/kg b.w.) to induce diabetes. Ninety days after diabetes diagnosis, animals were sacrificed and the ventral prostate was removed and prepared for general and immunohistochemical analyses. The total area showing different types of lesions was estimated. Diabetes led to a decrease in the body and prostatic weights, as well as in testosterone levels. The prostate morphology and stereology showed high variation in the diabetic group. Some animals had light changes; the great majority had an intense epithelial atrophy; and other rats showed premalignant and malignant lesions in the prostate. Such epithelial atrophy was, in some samples, combined with chronic inflammation, similar to proliferative inflammatory atrophy (PIA). The diabetic group also presented high incidence of prostatitis, adenocarcinoma and prostatic intra-epithelial neoplasia (PIN). Samples with adenocarcinoma had poorly differentiated acini with high levels of cellular proliferation and nuclear atypia. These lesions exhibited an invasive fea...Continue Reading

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Citations

Oct 22, 2011·Micron : the International Research and Review Journal for Microscopy·Marina Guimarães GobboRejane Maira Góes
Aug 8, 2009·International Journal of Experimental Pathology·Daniele Lisboa RibeiroRejane Maira Góes
May 11, 2012·Journal of Cellular Biochemistry·Marina Guimarães GobboRejane Maira Góes
Nov 3, 2010·International Journal of Experimental Pathology·Wagner J Fávaro, Valéria H A Cagnon
Jan 1, 2010·International Journal of Experimental Pathology·Fanny Oliveira ArcolinoRejane Maira Góes
Dec 23, 2014·International Journal of Experimental Pathology·Silas Amâncio SilvaDaniele Lisboa Ribeiro
Jun 13, 2015·Oxidative Medicine and Cellular Longevity·Marina G GobboRejane M Góes
Feb 20, 2015·BioMed Research International·Indraneel SahaUrmi Chatterji
Nov 15, 2017·Human Reproduction Update·Constanze C MareschThomas Linn
Sep 15, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Basma G EidHany M El-Bassossy
Feb 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Sebastião Roberto TabogaRejane Maira Góes
Aug 7, 2021·Journal of Anatomy·Luis SantamaríaFernando Teba

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