PMID: 3759075Sep 1, 1986Paper

Malignant lymphoepithelial lesion of the salivary gland

Human Pathology
D SawC S Ng

Abstract

Eight cases of malignant lymphoepithelial lesion (MLEL) of major salivary glands, seven of which occurred in Southern Chinese patients, are reported. All but two of the patients were older than 40 years of age; there were five male and three female patients. The parotid and submandibular glands were the sites of origin in equal numbers of cases. Six patients had elevated titers of serum IgA against Epstein-Barr virus capsid antigen. Seven remained well after surgery and local radiation therapy, and one died of miliary tuberculosis without evidence of residual neoplasm. Histologically, MLELs were characterized by syncytial clumps of large cells with vesicular nuclei and prominent nucleoli, admixed with abundant small lymphocytes and plasma cells. Two features not emphasized previously in the literature were the presence of reactive histiocytes in some epithelial islands, producing a starry sky pattern, and perineural invasion, which was identified in four cases. The tumor cells showed strong immunostaining for cytokeratin. The literature concerning this rare tumor is reviewed, and the differential diagnosis between MLEL and benign lymphoepithelial lesion, metastatic undifferentiated carcinoma, and malignant lymphoma is discussed.

Citations

Dec 11, 2007·Pathology International·Shiro AdachiTetsuro Kobayashi
Feb 14, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Delia Perez-MontielSaul Suster
Apr 1, 1993·International Journal of Cancer. Journal International Du Cancer·L LeonciniP Tosi
Mar 2, 2006·Virchows Archiv : an International Journal of Pathology·Hermann Herbst, Gerald Niedobitek
Mar 28, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Yao-Chung HsuChih-Ying Su
Jan 13, 2000·American Journal of Clinical Pathology·C ZhangD C Chhieng
Oct 24, 2012·Journal of Surgical Oncology·Kuo-Hung HuangHwa-Li Kao
Feb 3, 2021·Surgical Pathology Clinics·Lester D R Thompson, Rumeal D Whaley
Dec 1, 1993·The Journal of Laryngology and Otology·A DündarA Ozünlü
Aug 1, 1998·Japanese Journal of Cancer Research : Gann·S KojyaK Aozasa
Feb 1, 1992·Japanese Journal of Cancer Research : Gann·Y MatsunoY Shimosato
Sep 1, 1995·Head & Neck·S E KountakisA Maillard
Jun 5, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Hye Jae ChoSang Sook Lee
May 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·T C ChenT Kuo
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·K OhshimaN Kimura
Nov 1, 1996·Head & Neck·A K Abdulla, M Y Mian
Jun 11, 2005·Virchows Archiv : an International Journal of Pathology·Akira KuroseTakashi Sawai
Dec 1, 1996·The American Journal of Dermatopathology·B C BastianE B Bröcker
Sep 1, 2005·International Urology and Nephrology·Servet GuresciKemal Kutlu
May 1, 1997·The Annals of Otology, Rhinology, and Laryngology·A FerlitoL Barnes
Jan 1, 2009·Rare Tumors·Soumaya Ben AbdelkrimBadreddine Sriha
Jan 1, 2011·Case Reports in Otolaryngology·Orit Kaidar-PersonSalem Billan
Apr 13, 2001·Archives of Pathology & Laboratory Medicine·P Naidoo, R Chetty
May 23, 2007·Archives of Pathology & Laboratory Medicine·Matthew A Zarka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Farzana Mahomed, Wayne Grayson
Acta Pathologica Japonica
M KitazawaE Kobayashi
© 2021 Meta ULC. All rights reserved