PMID: 16501834Feb 28, 2006Paper

Malignant lymphoma in patients with systemic rheumatic disease (rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and dermatomyositis): a clinicopathologic study of 24 Japanese cases

International Journal of Surgical Pathology
Masaru KojimaShigeo Nakamura

Abstract

We conducted clinicopathologic and immunohistochemical analyses of the prevalence of Epstein-Barr virus (EBV) among 24 patients with malignant lymphoma complicating systemic rheumatic diseases. (SRD) These 24 patients included 17 with rheumatoid arthritis (RA), 3 with systemic lupus erythematosus (SLE), 2 with systemic sclerosis (SS), and 2 with dermatomyositis (DM). There were 2 men and 22 women ranging in age from 30 to 86 years (mean: 64 years). The interval between the onset of rheumatic disease and that of malignant lymphomas ranged from 3 months to 35 years (mean: 142 months). The use of immunosuppressive drugs before the onset of malignant lymphoma was recorded in 15 patients. Among them, 5 patients received methotrexate (MTX) therapy. Malignant lymphomas were found at extranodal sites in 9 patients, and the disease was in the advanced stage in 17 patients. Histologic and immunohistochemical studies demonstrated that 18 cases (75%) were B-cell lymphoma (RA=12, SLE=2, SS=2, DM=2), 3 (12.5%) were peripheral T-cell lymphoma (RA=3), and 3 (12.5%) were classical Hodgkin lymphoma (RA=2, SLE=1). As in previous reports, there was an increased frequency of diffuse large B-cell lymphoma (50%) in the present series. Moreover, a maj...Continue Reading

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Citations

Oct 8, 2009·Clinical Rheumatology·Serena VettoriGabriele Valentini
Nov 13, 2009·Journal of Clinical and Experimental Hematopathology : JCEH·Masaru KojimaHiroshi Inagaki
Dec 3, 2010·Journal of Clinical and Experimental Hematopathology : JCEH·Masaru KojimaShigeo Nakamura
Jan 11, 2013·Annals of the Rheumatic Diseases·Sasha BernatskyAnn E Clarke
Mar 14, 2012·Autoimmunity Reviews·Éva SzekaneczZoltán Szekanecz
Jul 14, 2009·Best Practice & Research. Clinical Rheumatology·Sasha BernatskyAnn E Clarke
Feb 6, 2009·Annales de chirurgie plastique et esthétique·G DrossardV Darsonval
Oct 27, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M KojimaS Nakamura
Jul 25, 2006·Pathology, Research and Practice·Masaru KojimaShigeo Nakamura
Jan 15, 2015·Immunologic Research·Dana Butnaru, Yehuda Shoenfeld
Feb 27, 2020·International Journal of Rheumatic Diseases·Vadim Romanovich GorodetskiyVladimir Ivanovich Vasilyev

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