Malignant melanoma in organ allograft recipients

Transplantation
I Penn

Abstract

Three groups of tumors were studied. The first group was melanomas inadvertently transmitted from donors. Brain metastases from melanoma were often misdiagnosed in the donors as primary brain tumors or cerebral hemorrhage. Eleven donors provided organs to 20 recipients of whom 3 never manifested evidence of melanoma, 1 showed local spread of tumor beyond the allograft, and 16 had metastases. Of the last group 11 died from melanoma, but 4 patients had complete remissions following transplant nephrectomy and discontinuation of immunosuppressive therapy. The second group was Melanomas treated pretransplantation. Thirty patients had cutaneous melanomas and one an ocular melanoma. Six patients (19%) had recurrences posttransplantation. Three were treated < 2 years pretransplantation, 2 between 2-5 years pretransplantation, and one 120 months pretransplantation. The third group was De novo melanomas. Cutaneous melanomas occurred in 164 patients, melanomas of unknown origin in 8, and ocular melanomas in 5. Melanomas constituted 5.2% of posttransplant skin cancers compared with 2.7% in the general population. Unusual features of cutaneous melanomas were that 6 (4%) occurred in children, and 9 (5%) occurred in bone marrow recipients who...Continue Reading

References

Dec 1, 1992·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·L J WilsonM Huntrakoon
Mar 1, 1991·Clinical and Experimental Dermatology·J M McGregorD M MacDonald
Mar 1, 1991·Journal of the American Academy of Dermatology·T MerkleO Braun-Falco
Mar 1, 1988·Clinical and Experimental Dermatology·J N Barker, D M MacDonald
Jun 1, 1986·World Journal of Surgery·A G Sheil
Jun 1, 1972·Transplantation·D JeremyG F Murnaghan
Nov 22, 1980·Lancet·F M YounisJ Moorhead
May 30, 1981·Lancet·M H GreeneW H Clark
Jan 1, 1984·Medical Decision Making : an International Journal of the Society for Medical Decision Making·G J CuchuralS G Pauker
May 1, 1980·Transplantation·E K SpeesL E Zimmerman
Nov 1, 1980·Transplantation·R M FairmanL J Perloff
Mar 9, 1995·The New England Journal of Medicine·P I CeballosM C Mihm
Jan 1, 1993·Transplant International : Official Journal of the European Society for Organ Transplantation·I Penn

❮ Previous
Next ❯

Citations

Jul 11, 2009·Inflammatory Bowel Diseases·Maria MoscandrewSunanda Kane
May 1, 1997·Clinics in Dermatology·J N Bouwes Bavinck, R J Berkhout
Aug 26, 2010·Nature Reviews. Nephrology·Inés Rama, Josep M Grinyó
Feb 7, 2003·The New England Journal of Medicine·Rona M MacKieBrian Junor
Apr 25, 2003·The New England Journal of Medicine·Sylvie EuvrardAlain Claudy
May 16, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Brigitte Dreno
May 29, 2004·Current Opinion in Otolaryngology & Head and Neck Surgery·Christine G Gourin, David J Terris
Apr 22, 2005·Dermatologic Therapy·Carmen Traywick, Fiona M O'Reilly
Oct 22, 2009·Pigment Cell & Melanoma Research·Liliana Ossowski, Julio A Aguirre-Ghiso
Mar 23, 2004·Annual Review of Immunology·Gavin P DunnRobert D Schreiber
Dec 12, 2012·Journal of Skin Cancer·Faisal R Ali, John T Lear
Mar 24, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Gianpaolo TessariAnnalisa Barba
Jan 1, 2013·Journal for Immunotherapy of Cancer·Stefani Spranger, Thomas Gajewski
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·I Kuijken, J N Bavinck
Nov 5, 2010·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Lucie KalinovaPetr Bachleda
Dec 22, 2012·Case Reports in Transplantation·Kathryn T ChenJeffrey M Farma
Apr 6, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Henry W Randle
Dec 24, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kiyanna WilliamsSarah Tuttleton Arron
May 17, 2014·Transplantation Research·Erin DahlkeAn-Wen Chan
Jan 5, 2011·Clinical & Developmental Immunology·Georg EschenburgHolger N Lode
Jul 13, 2014·American Journal of Clinical Dermatology·Lauren BrinJerry D Brewer
Jan 27, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jerry D BrewerAmy L Weaver
Jan 12, 2011·Annual Review of Immunology·Matthew D VeselyMark J Smyth
Apr 28, 2011·Seminars in Immunopathology·Michael Campoli, Soldano Ferrone
Sep 22, 2007·Melanoma Research·Michael G E O'RourkeChristopher W Schmidt
Aug 1, 2013·Clinical & Translational Immunology·David E GyorkiCharlotte E Ariyan
Jan 29, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sarah T ArronEric A Engels
Feb 18, 2014·Critical Reviews in Oncology/hematology·Stefan RodicRamy R Saleh
Mar 19, 2014·Pediatric Clinics of North America·Elena B Hawryluk, Marilyn G Liang
Jan 30, 2013·Medical Hypotheses·Andrew Kelly Johnson
Jan 19, 2016·Journal of the American Academy of Dermatology·Vanessa L PascoeAlexandra Boer Kimball
Oct 6, 2012·Mayo Clinic Proceedings·Agnieszka W Kubica, Jerry D Brewer
May 5, 2011·Seminars in Cutaneous Medicine and Surgery·Meena K Singh, Jerry D Brewer
Apr 23, 2011·Clinics in Chest Medicine·Hilary Y Robbins, Selim M Arcasoy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Dale HanStanley P Leong
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Lazar VujanovicWalter J Storkus
Surgical Oncology Clinics of North America
Paxton V Dickson, Jeffrey E Gershenwald
© 2021 Meta ULC. All rights reserved