Malignant melanoma: Mayo Clinic experience

Mayo Clinic Proceedings
F H SimD J Pritchard

Abstract

To present the Mayo Clinic experience with treatment of melanoma of the trunk and extremities, we reviewed previous Mayo Clinic studies on the management of malignant melanoma and summarized the survival data and treatment-related outcome. A prospective trial involving elective lymph node dissection in 171 patients with malignant melanoma showed no advantage in overall survival and disease-free survival in the group whose nodes were removed. In an assessment of the treatment variables, a Cox stepwise multiple regression analysis showed a strong correlation of lesion thickness and level of invasion with survival. Another study of 535 patients with melanomas that involved the trunk and extremities, who were treated at the Mayo Clinic between 1971 and 1980, showed an overall survival of 83%. Patients with thin lesions (less than 0.76 mm thick) had a 98% 5-year survival, whereas patients with lesions 4 mm thick or thicker had only a 45% 5-year survival. Because the Mayo Clinic prospective randomized study showed no benefit for patients with melanoma who undergo immediate or delayed lymphadenectomy in the trunk and extremities, we do not perform elective lymph node dissection; however, close follow-up of patients is instituted, and ...Continue Reading

Citations

Apr 12, 2003·Langenbeck's Archives of Surgery·Claus SchneiderFerdinand Köckerling
Jun 3, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Chun-Hua WangShih-Tsung Cheng
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gheath AlatrashRonald M Bukowski
Nov 2, 2006·The Journal of the American Academy of Orthopaedic Surgeons·Ann-Marie PlateMartin A Posner
Sep 26, 2002·World Journal of Surgery·Markwin G Statius MullerSybren Meijer
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J C L M VuylstekeS Meijer
Sep 14, 2011·Current Problems in Cancer·Mark B Faries, Stephan Ariyan

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