PMID: 3759321Jan 1, 1986Paper

Malignant melanoma of the vulva: a clinical-pathologic review of 16 cases

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
J A BendaB Anderson

Abstract

A study of 16 malignant melanomas of the vulva was undertaken to identify the histologic variants found on the vulva and to evaluate the use of microstaging as a predictor of behavior. Ten of 16 cases were melanoma of mucous membrane (MMM) type of acral lentiginous melanoma. This percentage (63%) is notably higher than in previous reports. Three cases were nodular melanoma (NM). All lesions of MMM and NM type occurred on mucous membranes. Three cases were superficial spreading melanoma and all occurred on skin. Neurotropism was observed in 5 of the 10 MMM. Neurotropic melanoma has been reported only once previously in the vulva. Depth of the melanomas was greater than 1.0 mm in 13 of the 16 cases. This correlated with Clark and Chung levels of 3 or higher in the same 13 cases. A poor outcome with an overall 5 year survival of 20% of cases with invasive disease was found. The poor outcome and large number of thick lesions would suggest a correlation, but the distribution is skewed and number of cases too small for statistical documentation.

Citations

Jan 1, 1996·Archives of Gynecology and Obstetrics·A UlmerG Fierlbeck
Oct 1, 1995·Obstetrical & Gynecological Survey·C J DuntonC Hanau
Oct 1, 1995·Journal of Cutaneous Pathology·R L Barnhill, J L Bolognia
Jul 1, 1993·Cancer·K Y LookG P Sutton
Jan 1, 1995·Cancer·C E Platz, J A Benda
Feb 1, 1990·British Journal of Obstetrics and Gynaecology·M G BradgateJ Powell
Nov 1, 1994·The British Journal of Ophthalmology·K ColemanJ Mullaney
Aug 1, 1990·The British Journal of Ophthalmology·C M AntleJ Rootman
Nov 20, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Priyadharsini NagarajanMichael T Tetzlaff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Obstetrics and Gynecology
J R KarlenJ J Barlow
British Journal of Obstetrics and Gynaecology
M G BradgateJ Powell
Gynecologic Oncology
K C PodratzP C O'Brien
Gynecologic Oncology
E L TrimbleW J Hoskins
© 2021 Meta ULC. All rights reserved