PMID: 8941006Dec 1, 1996Paper

Malignant melanoma of the vulva. Report of 89 patients

Cancer
G RäberH P Schneider

Abstract

Rates of melanoma have increased worldwide over the last few decades. Currently, this rate of increase is greater for melanoma than for any other cancer in the U.S. Approximately 3% of all melanomas diagnosed in women are located within the genital tract, predominantly affecting the vulva. Overall, melanomas of the vulva account for 2-10% of all malignancies of the female external genitalia. Due to the rarity of this disease, treatment recommendations do not exist. This retrospective study was designed to evaluate the significance of clinical and pathologic features for survival among 89 patients examined for malignant melanoma at 5 hospitals in Germany from 1978 to 1991. A complete workup based on age, initial symptoms, tumor localization, presence of ulceration, postoperative stage, surgical procedure, and survival, was performed. The overall 5-year survival rate of 36.7% confirms the poor prognosis of this disease. Definitive treatment concepts require a standardized treatment of patients with malignant melanoma of the vulva; however, because of the rarity of vulvar melanomas, prospective studies are difficult to perform. Parameters such as age, Breslow's thickness of invasion, Clark's level of invasion, lymph node involveme...Continue Reading

References

Feb 1, 1975·Obstetrics and Gynecology·J R KarlenJ J Barlow
Jun 11, 1975·Obstetrics and Gynecology·A F ChungJ L Lewis
Apr 1, 1976·Obstetrical & Gynecological Survey·C P Morrow, P J DiSaia
Aug 1, 1992·Journal of Surgical Oncology·B PiuraJ M Monaghan
Feb 1, 1990·British Journal of Obstetrics and Gynaecology·M G BradgateJ Powell
Jul 1, 1988·American Journal of Obstetrics and Gynecology·P G RoseT Lau
Jan 1, 1986·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·T L JohnsonG W Morley
May 17, 1985·Deutsche medizinische Wochenschrift·M LandthalerJ Zander
Oct 1, 1983·Gynecologic Oncology·K C PodratzP C O'Brien
Aug 1, 1982·Gynecologic Oncology·G L PhillipsT Okagaki
Jun 1, 1982·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J BoumaA Elders
May 1, 1980·British Journal of Obstetrics and Gynaecology·P T Edington, J M Monaghan
May 15, 1993·Cancer·L RyanE Borden
Jul 1, 1993·Cancer·K Y LookG P Sutton

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Citations

Jul 6, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mario M LeitaoGilles Freyer
Feb 25, 1999·The Australian and New Zealand Journal of Surgery·K B LarssonW H McCarthy
Dec 12, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C F VerschraegenS S Legha
Aug 12, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·N J KingstonJ Baranyai
Jan 17, 2012·Journal of the American Academy of Dermatology·Win J TcheungKelly C Nelson
Dec 16, 2003·Skinmed·Jabob Mashiah, Sarah Brenner
Sep 18, 2010·The British Journal of Dermatology·S Ronger-SavleL Thomas
Jul 20, 1999·Dermatologic Clinics·C R Shea, V G Prieto
Jun 1, 2010·São Paulo Medical Journal = Revista Paulista De Medicina·Glauco BaiocchiLeonardo Jacomo Valadares
May 7, 2004·Current Opinion in Obstetrics & Gynecology·Joanne A de HulluAte G J van der Zee
Mar 22, 2002·Cancer·Joanne A de HulluAte G J van der Zee
Aug 2, 2007·Obstetrics and Gynecology·Valerie E SugiyamaDaniel S Kapp
May 28, 2009·Archives of Gynecology and Obstetrics·Kaei NasuHisashi Narahara
May 27, 2014·American Society of Clinical Oncology Educational Book·Mario M Leitao
Dec 13, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Christoph Wohlmuth, Iris Wohlmuth-Wieser
Dec 4, 2004·Melanoma Research·Mandy S Harting, Kevin B Kim
Jul 26, 2002·The American Journal of Dermatopathology·Angela RohwedderJ Andrew Carlson
Jul 24, 2001·Obstetrical & Gynecological Survey·A Isenberg, D Paul Shackelford
Jun 9, 2020·Journal of Cutaneous Pathology·Karina FurlanPaolo Gattuso
Feb 19, 2014·International Journal of Molecular Medicine·Viola A Heinzelmann-SchwarzJames P Scurry
Aug 1, 2015·Journal of Lower Genital Tract Disease·Marjan RouzbahmanDanny Ghazarian
Dec 30, 1998·Annals of Surgical Oncology·P DeMatosH F Seigler
Dec 1, 2019·American Journal of Clinical Dermatology·Christoph WohlmuthStéphane Laframboise
Nov 20, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Priyadharsini NagarajanMichael T Tetzlaff
Jun 15, 2021·American Journal of Clinical Dermatology·Christoph Wohlmuth, Iris Wohlmuth-Wieser

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