PMID: 7525666Nov 1, 1994Paper

Malignant melanoma with clinical and histologic features of Merkel cell carcinoma

Journal of the American Academy of Dermatology
N S HouseK F Helm

Abstract

We describe a patient with malignant melanoma that resembled a Merkel cell carcinoma both clinically and histologically. Immunohistochemical studies showed focally positive staining with S-100 protein and strongly positive staining with HMB-45. Ultrastructural study confirmed the diagnosis by demonstrating premelanosomes and melanosomes. Although the tumor appeared to be clinically unimpressive, it was a deep melanoma with a Breslow level of 3.8 mm that necessitated aggressive treatment. Small cell melanoma must be considered in the differential diagnosis of small cell tumors, which also includes lymphoma, eccrine carcinoma, squamous cell carcinoma, and Merkel cell carcinoma. The diagnosis of amelanotic melanoma, including the small cell variant, may require electron microscopic studies.

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Citations

May 23, 2009·The American Journal of Dermatopathology·Marjan MirzabeigiPedram Gerami
Oct 20, 2011·The American Journal of Dermatopathology·Larisa M LehmerKevin L Ferguson
Jul 27, 2000·Journal of Clinical Pathology·S L Edwards, K Blessing
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Jun 25, 2004·The British Journal of Dermatology·M A PizzichettaH P Soyer
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Feb 1, 1997·The British Journal of Dermatology·T KatoH Tagami
Sep 22, 2020·The American Journal of Dermatopathology·Yali SongYing Guo

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