Malignant mesenchymoma of the uterus, arising in a leiomyoma

Histopathology
M A den BakkerW N M Dinjens

Abstract

To document and find evidence for the rare occurrence of malignant progression of a benign uterine leiomyoma with divergent mesenchymal differentiation. In a 54-year-old female a large pedunculated tumour was encountered which had suddenly increased in size and had apparently arisen at the site of a subserosal uterine leiomyoma first described 19 years earlier. The tumour seemed histologically diverse in its composition. The possibility of malignant progression of the benign leiomyoma with divergent mesenchymal differentiation was entertained. In the resected tumour, smooth muscle, osseous and adipose components were identified and these were assessed using recognized histological criteria of malignancy. In addition to a benign smooth muscle component, malignant leiomyosarcomatous tissue was seen in addition to a malignant osseous component and a malignant adipose component. The tumour thus met the criteria of a malignant mesenchymoma. The relationship of the different components of the tumour was analysed by immunohistochemistry and with molecular loss of heterozygosity (LOH) analysis. In the osseous and leiomyosarcomatous components a similar LOH pattern was observed. The adipose component showed a distinct LOH pattern. Reten...Continue Reading

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Citations

Feb 20, 2009·Archives of Gynecology and Obstetrics·Mrinalini KotruArati Bhatia
Sep 23, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Pascale Hummel LevineStephanie V Blank
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